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DOI: 10.18413/2313-8955-2015-1-3-5-14

PROJECTED NON-DRUG COMPLICATIONS IN THERAPY WITH USING OF INFUSION SOLUTIONS

Currently, an infusion solutions in glass vials, sealed with rubber stoppers commonly presented in the turnover of drugs. These stoppers are made with using of carbon disulfide as solvent rubber. By medicines storing carbon disulfide is released from the material accumulation and plugs it into a dosage form. The presence of these carbon disulfide impurities in medicaments is unacceptable. Carbon disulfide is a substance of Class 2 toxicity. Lethal dose admission inside is 1 gram. Provides local irritant, resorptive action. It has psychotropic, nephrotoxic properties that relate to its narcotic effects on the central nervous system. To study the breadth of the problem indicated by a group of authors have conducted pilot studies of a number of drugs for infusion.

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