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DOI: 10.18413/2313-8955-2015-1-3-151-158

PROSPECTS FOR THE USE OF GROWTH FACTORS IN BONE TISSUE REGENERATION. LITERATURE REVIEW

Currently, scientists are searching for new pharmacological agents, whose addition to osteoplastic material implants will help improve microcirculation in the area of surgery, accelerated germination vessels and bone regeneration at the site of the defect. The search for products, contributing to the restoration of microcirculation and acceleration of regeneration of bone tissue, both in experimental and clinical conditions, after surgery on the jaw bone, is challenging for surgical dentistry and maxillofacial surgery. Continuously regenerating tissues require a strict regulation of stem cell proliferation. The required regulation of cell proliferation, differentiation and cell motility by means of various mechanisms. One of them is the interaction of cells with growth factors. Currently, there are the following factors stimulating new bone formation: 1 IGF1; PDGF; TGF-ß; EGF; FGF (1 IGF1 or IGF − insulin-like growth factor, TGF-ß or TGF-β − transforming growth factor beta, EGF, or EGF − epidermal growth factor FGF − fibroblast growth factor).

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