RATIONALE FOR DEVELOPMENT OF THE COMPOSITION AND TECHNOLOGIES OF A COMPOUND PREPARATION FOR THE TREATMENT OF UROLITHIASIS
Since ancient times, kidney stone disease has been the most common condition characterized by the formation of calculi (stones) in the cavities of the kidneys and bladder. Over the past few years there was a 25.8% increase in the number of visits of patients with this disease to the doctor (Apolikhin O.I., 2011), indicating that there is a trend of increasing the incidence of urolithiasis. The treatment of urolithiasis involves the use of specific drugs. In this regard, the study of the range of drugs registered in Russia, as well as the drugs which are not currently registered in Russia, but have a broad application in the treatment of kidney stones and gout is important worldwide. The aim of this research is to study a complex technology of creating an effective and safe drug for the treatment of urolithiasis. Content analysis was used as the method of the study, which implies a processing of information in order to detect or measure different facts and trends. The study revealed that the most commonly used drugs are allopurinol, Adenurik, Dezurik, the therapeutic effect of which is determined by different mechanisms of action aimed at reducing the production of uric acid and its concentration in the blood and urine.