APPLICATION OF DIFFERENT THICKENER-PROLONGATORS OF THE KOLLIDON GRADES IN THE PHARMACEUTICAL TECHNOLOGY
The article provides an overview and comparative characteristics of various polyvinylpyrrolidone grades, widely used in modern industrial production of drugs. It was found that the main characteristics of this group of adjuvants is the ability to influence the solubility of the active ingredients and their release, to act as disintegrants, binders, film formers and fillers to reduce the irritant effect of certain substances (in contact with mucous membranes), to provide thickening and prolongation of a part of ophthalmic formulations. One of the major manufacturers of Kollidon is a German company BASF, which produces insoluble polyvinylpyrrolidone grades (Kollidon CL, Kollidon CL-M, Kollidon SR), and water-soluble (Kollidon 12 PF, Kollidon 17 PF, Kollidon 25, Kollidon 30, Kollidon 90 F , Kollidon VA 64). Owing to their wide range of properties, Kollidons are used in most dosage forms, preferably tablets (including in the coating composition), eye drops and gels.