Research Results in Biomedicine
Volume 8, Issue №4, 2022
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Genetics
Molecular cytogenetic and cytopostgenomic analysis of the human genome
Background: Despite the achievements of human genomics, comprehensive genome analysis, including acquiring the knowledge about intercellular and interindividual variations at (sub)chromosomal/cytogenomic level, remains a difficult task. This basically results ...
Study of the exosomal microRNA-126 and microRNA-218 expression profiles in patients with hemorrhagic fever with renal syndrome (HFRS)
Background: Hemorrhagic fever with renal syndrome (HFRS), caused by orthohantaviruses, occupies one of the leading places among natural focal human diseases, for which there are no modern accurate and highly ...
Association of the rs10508336 polymorphism of the TAF3 transcription factor gene with the risk of lower limb arterial disease in the Russian population
Background: Atherosclerosis obliterans (AO) and diabetic angiopathy (DA) are known to be peripheral artery diseases (PAD) of multifactorial origin, in which genetic and environmental factors play a synergetic role. ...
Knock-out of α-, β-, and γ-synuclein genes in mice leads to changes in the distribution of several lipids in the liver and blood plasma
Background: In addition to the role of synuclein proteins in synaptic transmission through binding with lipid membranes, the function of synucleins in reactions of the synthesis of lipids and ...
Pharmacology
The role of cortisol metabolism in the realization of pathogenetic links in the development of osteoporosis – the rationale for the search for new pharmacotherapeutic targets (review)
Background: Osteoporosis is an important medical and social public health problem in an aging or elderly society. Osteoporosis is caused by an imbalance in bone remodeling, which is a ...
Pathological conditions associated with tau protein: mechanisms of development and possible biological targets for pharmacological correction of tau proteinopathy (review)
Background: The pathological process associated with the pathogenic aggregation of tau is called taupathy. The same term is often used to refer to a group of neurodegenerative diseases, an ...
Medicine (miscellaneous)
Coexistence of Urinary Incontinence and Osteoporosis in Females – A Systematic Review
Background: Urinary incontinence (UI) is described as the involuntary leakage of urine and is a global problem. The younger age groups have the lowest prevalence (12.0%), while the oldest ...
"The blue zones" resilience-diet (review)
Background: Given the progressive aging of the population, the problem of extending healthy longevity while maintaining high vitality is very important. The "blue zones" – the regions with the ...
Social functional activity of patients with diabetic retinopathy
Background: Diabetic retinopathy, the prevalence of which is intensively increasing, is considered to be a potential factor causing a significant visual deficit in older age groups. However, when studying ...
Visual deficit and geriatric status of rural patients with various ophthalmic pathologies
Background: Diseases of the visual organ negatively affect the quality of life of the elderly. A comprehensive study of the pathology of the visual organ among the elderly population ...
