The applicability of interphase chromosome-specific multicolor banding (ICS-MCB) for studying neurodevelopmental and neurodegenerative disorders
Background: Interphase chromosome-specific multicolor banding (ICS-MCB) has been developed for studying whole chromosomes in interphase nuclei at any stage of the cell cycle at molecular resolution. Previously, important biomedical discoveries have been made using the technique. In the postgenomic era, a need appears to exist for a reevaluation of molecular cytogenetic techniques, including ICS-MCB, which seems to take a well-deserved place. Aim of the study: The aim of the present study is to address the applicability of ICS-MCB for studying neurodevelopmental and neurodegenerative disorders. Conclusions: A brief overview of previous ICS-MCB applications demonstrates that the technique may provide an appreciable amount of unique data on chromosome abnormalities and organization in interphase nuclei. Furthermore, the technique offers opportunities for evaluating these phenomena in the diseased human brain. Such opportunity seems to be critical for unraveling molecular and cellular mechanisms of neurodevelopmental and neurodegenerative disorders. Therefore, we conclude that ICS-MCB may represent an important part of molecular and cellular studies of neurodevelopmental and neurodegenerative disorders.