Pharmacological efficiency of combined eye drug films based on Levofloxacin and Dexpanthenol, and also Dexamethazone and Dexpanthenol in the treatment of infected corneal injury
Background: When treating infected corneal burns, some patients are not able to comply with the schedule of frequent instillations of drugs, which entails a persistent irreversible decrease in visual acuity due to the formation of corneal opacities. The aim of the study: To increase the effectiveness of treatment of infected corneal burns using combined ophthalmic medicinal films based on Levofloxacin and Dexpanthenol, as well as Dexamethasone and Dexpanthenol. Materials and methods: 1 hour after the formation of a standard infected corneal burn, the comparison group was treated according to the classical method using instillations, and the experimental group was treated with combined ophthalmic medicinal films based on Levofloxacin and Dexpanthenol, as well as Dexamethasone and Dexpanthenol. The area of the defect in the corneal epithelium was recorded. Morphological examination with hematoxylin-eosin staining was carried out according to the standard technique at different periods of observation. Results: A pronounced cellular reaction was recorded already 1 hour after the formation of a standard infected corneal burn. The defect area of the corneal epithelium decreased faster in the group treated with combined ophthalmic drug films. The thickness of the outer corneal epithelium, as well as the number of cells in its layers, returned to normal on the 3rd day in the experimental group, and in the comparison group with treatment according to the standard method on the 5th day of the experiment. When examining the thickness of the corneal endothelium, there were no statistically significant differences from the normal cornea. Conclusion: In the treatment of a standard infected corneal burn, the use of combined ophthalmic medicinal films can reduce the process of morphological restoration of the cornea to 3 days, in comparison with treatment using instillations, where the cornea is restored to the parameters of an intact eye on the 5th day.
Yarmamedov DM, Medvedeva MV, Lipatov VA, et al. Pharmacological efficiency of combined eye drug films based on Levofloxacin and Dexpanthenol, and also Dexamethazone and Dexpanthenol in the treatment of infected corneal injury. Research Results in Biomedicine. 2021;7(4): 388-399. Russian. DOI: 10.18413/2658-6533-2021-7-4-0-5
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