Pharmacological potential of ar-turmerone and study of the extractive potential of fluorinated alkane derivatives for its isolation from the rhizomes of Curcuma longa L.
Background: Ar-turmerone is one of the main components of the essential oil of the rhizomes of Curcuma longa L. It determines the specificity of the composition of the essential oil of the rhizomes of C. longa L. The prospects of this component are due to a whole set of important pharmacological properties. Since ar-turmerone is a component of essential oil, a number of options typical for essential oils are used for its extraction: hydrodistillation, extraction with organic solvents, liquefied gases, including CO2. The least studied effect of freons on the extraction of ar-turmerone. The use of this type of solvents has a number of significant advantages over the above, including non-toxicity, incombustibility and non-explosiveness, low boiling point, selectivity, low viscosity. The specified spectrum of freon qualities makes them very promising for the extraction of ar-turmerone. The aim of the study: To substantiate the expediency of using fluorochlorine derivatives of alkanes as promising extractants for isolating the most important therapeutic agent of C. longa L. rhizomes, ar-turmerone. Materials and methods: The rhizomes of C. longa L., previously dried and crushed, were used as an object of research. Methoxynonafluorobutane (Novec 7100) and fluoroketone (do-decacafluoro-2-methylpentan-3-one, Novec 1230) were selected as extractants; n-hexane served as the reference extractant. The method of liquid chromatography – mass spectrometry was used to identify and quantify ar-turmerone in the analyzed samples. Chromatography was performed on a gas chromatograph – mass spectrometer – GCMS-QP2010 Ultra, Shimadzu, Japan. Ionization was carried out using electron impact, total ion current detection (SCAN). The separation was carried out on a capillary quartz column in the programmed temperature mode. Results: In the course of the analysis, it was found that in all samples subjected to extraction with the selected solvents, the dominant component is ar-turmerone, the content of which, depending on the solvent, in the obtained extracts varied from 35 to 40%. Methoxynonafluorobutane has the best extracting ability in relation to ar-turmerone. Conclusion: It was found that methoxinonafluorobutane is the optimal extractant for ar-turmerone; fluoroketone showed less extracting activity. The extraction ability of methoxynonafluoro-butane in relation to ar-turmerone was higher than that of the reference extractant, n-hexane. When it was used, the maximum amount of the analyzed compound passed into the extraction, and the content of ar-turmerone in the resulting total extraction exceeded 40%. In addition, methoxinonafluorobutane is non-toxic, non-flammable, and has a lower boiling point compared to n-hexane.
Pisarev DI, Boyko NN, Nikitin KS, et al. Pharmacological potential of ar-turmerone and study of the extractive potential of fluorinated alkane derivatives for its isolation from the rhizomes of Curcuma longa L. Research Results in Biomedicine. 2021;7(3):222-233. Russian. DOI: 10.18413/2658-6533-2023-9-2-0-6
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