NOS3 gene polymorphism variants and main characteristics of heart rate variability in Northerners
Background: Heart rate variability as a demonstration of autonomic nervous system function reflects human health and well-being. By monitoring heart rate variability indices and focusing on the imbalance with a decrease in parasympathetic activity and a simultaneous increase in sympathetic activity, we can prevent the development of cardiovascular diseases. Heart rate variability indices can be a marker of vertical integration, including adaptation processes that form brain stem activity and autonomic reactions in the body. Endothelial nitric oxide synthase is the main source of vascular nitric oxide, with its level variability being mainly determined genetically. However, the effect of nitric oxide on the autonomic control of the human heart still needs further investigation. The aim of the study: This study aimed to consider the incidence of -786 T>C (rs 2070744) polymorphism of the endothelial nitric oxide (NOS3) gene and its relationship with main characteristics of heart rate variability in northerners. Materials and methods: The cross-sectional study involved 127 northern men, predominantly Caucasians, living or born on the territory of the Magadan region. The examinees underwent gene typing, and the VARICARD complex was used to determine heart rate variability indices. Results: The ratio of the gene types through the studied polymorphism was as follows: T/T – 40,95%; T/C – 47,24%; C/C – 11,81% (corresponds to the Hardy-Weinberg equilibrium). The T/T gene type subjects demonstrated predominance of the parasympathetic link of the autonomic nervous system. Those having the mutant allele C of the endothelial nitric oxide gene exhibited elevated sympathetic activity in heart rhythm regulation, as well as significantly lowered variables of the very low-frequency component of the spectrum total power. Conclusion: The obtained results suggest that low variables of the very low-frequency component of the heart rhythm spectrum total power may represent an early non-invasive biomarker of a decrease in the level of endothelial nitric oxide as a predictor for a high risk of cardiovascular diseases and reduced quality of life in general.
Bezmenova IN, Averyanova IV. NOS3 gene polymorphism variants and main characteristics of heart rate variability in Northerners. Research Results in Biomedicine. 2023;9(4):486-499. Russian. DOI: 10.18413/2658-6533-2023-9-4-0-5
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