The role of mental disorders in the pathogenesis of atopic dermatitis (review)
Background: The problem of atopic dermatitis has received significant attention from researchers across different fields over the years. Despite its high prevalence, there remains an incomplete understanding of the underlying pathogenetic mechanisms, leading to ineffective therapeutic strategies. This lack of consensus regarding a unified model of dermatitis development creates challenges in selecting appropriate treatment options. The aim of the study:To analyze the current scientific literature data describing the relationship between central nervous system damage, psychogenic factors and the development of atopic dermatitis. Materials and methods: Data were searched in the electronic libraries of scientific articles PubMed, eLIBRARY.RU, and Google Scholar. A total of 41 publications corresponding to the objectives of the current review were analyzed. Results: Numerous studies highlight the dual contribution of exogenous (environmental) and endogenous (internal) factors in the etiology of atopic dermatitis. Psychogenic elements, particularly psychological stress, emerge as key drivers influencing disease progression. Recent advancements in psychoneuroimmunology underscore the profound effect of psychophysiological variables on immune responses. Additionally, a correlation exists between the degree of pathological changes, distribution of skin lesions, and the severity of associated psychopathological manifestations. However, these findings predominantly focus on adults, with less exploration into pediatric populations where mental health aspects are often overlooked. Current investigations typically prioritize cutaneous pathologies rather than considering broader implications related to systemic impacts. Conclusion: Further investigation into the interplay between psychogenic influences and individual personality traits could provide valuable insights into the mechanisms underpinning atopic dermatitis. Addressing the gaps in our knowledge concerning the contributions of intrinsic neurological anomalies and their consequences on autonomic-nervous and immunological balance may yield more effective diagnostic tools and therapies
Levintova NL, Keniksfest YuV, Retyunskiy KYu, et al. The role of mental disorders
in the pathogenesis of atopic dermatitis (review). Research Results in Biomedicine. 2025;11(4):699-
708. DOI: 10.18413/2658-6533-2025-11-4-0-8
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