Secondary metabolites of Reynoutria sachalinensis – a potential reserve of pharmacological drugs (review)
Background: This literature review focuses on the perennial herbaceous plant Reynoutria sachalinensis, which belongs to the Polygonaceae family. This species is considered invasive in many countries, and research is ongoing into methods to combat it and its potential use as a medicinal, honey-bearing, ornamental, food and fodder plant. The aim of the study:To systematize modern scientific data in the field of the chemical composition of R. sachalinensis, the mechanisms of action of its main biologically active compounds and the justification of their therapeutic use. Materials and methods: To achieve this goal, an analysis of the sources of national and foreign literature on this issue was carried out for the period from 2000 to 2025. Databases of scientific electronic libraries Google Scholar, eLibrary, PubMed, Web of Science, ScienceDirect, Scopus were used. Results: The review summarizes the results of research in the field of studying the chemical composition, biological activity of both various extracts and individual compounds, as well as the mechanisms of action of the main biologically active substances of R. sachalinensis. Currently, more than 277 compounds have been isolated and identified from this species. The metabolites of R. sachalinensis are phenolic compounds, triterpenoids, nitrogenous compounds, pigments and aliphatic alcohols. Studies in recent decades have shown that total extracts and highly purified fractions of compounds from various organs of R. sachalinensis have antioxidant, antiviral, fungicidal, and antitumor activity, inhibitory effects on beta-glucosidase, acarbose, acetylcholinesterase, xanthine oxidase, and neuroprotective properties. Knowledge of the spatial structure of complexes of cellular proteins, membrane receptors, and plant secondary metabolites, as well as their ligands, reveals the mechanism of action of biologically active substances, but does not exclude the need to confirm it and conduct experiments in vitro and in vivo. Conclusion: The plant raw materials of R. sachalinensis can be considered as a source of biologically active metabolites with a wide range of uses
Zhnichkova EG, Krol TA, Baleev DN. Secondary metabolites of Reynoutria sachalinensis – a potential reserve of pharmacological drugs (review). Research Results in Biomedicine. 2026;12(3):414-438. Russian. DOI: 10.18413/2658-6533-2026-12-3-0-4
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