DOI: 10.18413/2313-8955-2015-1-4-66-68

CORRECTION OF ADMA-INDUCED PREECLAMPSIA WITH THE USE OF PHOSPHODIESTERASE 5 AND SELECTIVE INHIBITOR OF ARGINASE II ZB49-0010

Vladimir V. Gureev
Olga V. Martynova
Oksana E. Antsiferova
Mikhail A. Martynov
Tatyana G. Pokrovskaia
Tatyana I. Lokteva

Simulation experimental ADMA-like preeclampsia was carried out by administering the rats with L-NAME during 14-20 days of pregnancy. In animals, there was an increase in blood pressure, proteinuria, impaired microcirculation in the placenta, the violation of the regulation of vascular tone and destructive changes in the ischemic placenta. The use of phosphodiesterase 5 and selective inhibitor of arginase II ZB49-0010 leads to the expression of morphological and functional correction of violations occurring in modeling of experimental preeclampsia

Keywords: rats, N-nitro-L-arginine methyl ester, endothelial dysfunction, preeclampsia, phosphodiesterase 5, a selective inhibitor of arginase II.

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Gureev VV, Martynova OV, Anciferova OE, et al. Correction of adma-induced preeclampsia with the use of phosphodiesterase 5 and selective inhibitor of arginase ii zb49-0010. Research Result. Medicine and Pharmacy Series. 2015;1(4):66-68 (In Russian). DOI: 10.18413 / 2313-8955-2015-1-4-66-68

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Adu-Bonsaffoh. Nitric oxide dysregulation in the pathogenesis of preeclampsia among Ghanaian women. / Adu-Bonsaffoh [et al.] Integr Blood Press Control. . – 2015. Vol. 19;8. P. 1-6.
Brandão A.H. Prediction of early and late preeclampsia by flow-mediated dilation of the brachial artery./ A.H. Brandão [et al.] Radiol Bras. – 2014. – Vol. 47(4). P. 206-9.
Fei X. Maternal plasma levels of endothelial dysfunction mediators including AM, CGRP, sICAM-1 and tHcy in pre-eclampsia. / X. Fei [et al.] Adv Clin Exp Med. 2012. Vol. 21(5). P. 573-579.
Groesch K.A. Nitric oxide generation affects pro- and anti-angiogenic growth factor expression in primary human trophoblast. Placenta. / K.A. Groesch [et al.] – 2011. Vol. 32(12). P. 926-931.
Wang A. Preeclampsia: the role of angiogenic factors in its pathogenesis. / A. Wang [et al.] Physiology (Bethesda). 2014. 24: 147–158.
Gureev V.V. Remote Ischemic Preconditioning Correction in Adma-Like Gestosis Model./ V.V. Gureev [et al.] Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2014. №5. Vol. 1095-1098.
Korokin M.V. Effect of L-arginine, vitamin B6 and folic acid on parameters of endothelial dysfunction and microcirculation in the placenta in modeling of L-NAME-induced NO deficiency./ M.V. Korokin [et al.]Bulletin of Experimental Biology and Medicine.-2011.-152(1): 70–72. doi: 10.1007/s10517-011-1456-z.
Pokrovsky M.V. Pharmacological correction of ADMA-eNOS-associated target in preeclampsia. / M.V. Pokrovsky[et al.] Obstetrics and Gynecology.2011. 2: 16-20.
Pokrovsky M.V. USE OF L-ARGININA IN CORRECTION OF ENDOTELIALNY DYSFUNCTION AT EXPERIMENTAL PREEKLAMPSIYA./ M.V. Pokrovsky [et al.] Experimental and clinical pharmacology. 2012. T. 75. No. 2. P. 14-16.
Gureev V. V. CORRECTION ADMA-LIKE GESTOZ IN EXPERIMENT./ V. V. Gureev [et al.] Bridge Ampere-second.Kursk scientific and practical bulletin "Chelovek I Ego Zdorovye". 2012. No. 1. P. 14-19.
Pokrovsky M.V. REALITIES AND PROSPECTS OF PHARMACOLOGICAL ORRECTION "ADMA-ENOS" - THE ASSOCIATED WAYS AT PREEKLAMPSIYA/ M.V. Pokrovsky [et al.] Rational pharmacotherapy in cardiology. 2010. T. 6. No. 6. P. 882-887.
Gureev V. V. INOS ROLE IN CORRECTION OF ENDOTELIALNY DYSFUNCTION AT ADMA-LIKE GESTOZ SHORT EPISODES OF ISHEMII-REPERFUZII IN EXPERIMENT/ V. V. Gureev [et al.] Basic researches. 2012. No. 8-2. P. 298-301
Gureev V.V. Correction of ADMA-like preeclampsia in an experiment using arginase inhibitor L-norvaline and preparations included in the standard treatment regimen./V. V. Gureev [et al.] Kursk scientific-practical herald "Man and his health.".2012. № 2. P. 14-20.

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