JUSTIFICATION AND DEVELOPMENT OF THE GRANULATED DOSAGE FORM FOR THE PREVENTION OF ATHEROSCLEROSIS AND NON-ALCOHOLIC STEATOHEPATOSIS
Atherosclerosis and nonalcoholic steatohepatosis are pathologies, which most often develop in both the elderly and senile age. According to the scientific literature, these pathologies have a similar pathogenesis, but, despite this, the pharmaceutical market of Russia is scarce of drugs aimed at their complex treatment. Taking into account the risk of polypharmacy in elderly patients, the development of the combined medicine in the form of pellets, aimed at prevention of non-alcoholic steatogepatosis and atherosclerosis, is relevant. The article gives the theoretical justification for the use of methionine, an extract from the fruit of Silybum marianum and vitamin B12 as a component of comprehensive geriatric drug action. The choice of auxiliary substances, the composition and concentration of humectant are experimentally substantiated. In the result, the composition of the pellet form for the treatment and prevention of non-alcoholic steatogepatosis and atherosclerosis was theoretically and experimentally proved.
Kuzmicheva OA, Zhilyakova ET, Tsvetkova ZE, et al. Justification and development of the granulated dosage form for the prevention of atherosclerosis and non-alcoholic steatohepatosis. Research Result. Medicine and Pharmacy. 2016;2(4):37-42 (In Russian). DOI: 10.18413/2313-8955-2016-2-4-37-42
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