THE DEVELOPMENT OF TECHNOLOGY FOR PRODUCTION AND STANDARDIZATION OF MONTMORILLONITE CLAY FOR PER OS USE
The article presents a technique of purification and a process scheme of montmorillonite clay production for per os use. It was established that the treatment process comprises the stages of elutriation, centrifugation, drying and machine processing. Cleaning of clay frees it from impurities and increases the fraction of useful component sorption-active mineral montmorillonite. The authors determined the linearity of the BET method (measurement of specific surface area and porosity) and conducted the evaluation of accuracy, reproducibility and standardization of the method for the determination of adsorption activity. There was revealed the exponential dependence of the adsorption activity of the mass of sample (0.8 g), the time of sorption (20 min) and the equilibrium concentration of dye solution (35 ml of 0.15 %). There were studied the physico-chemical, technological properties of montmorillonite clay for per os use. The authors found that the montmorillonite clay for per os use is a powder of light gray colour, odorless, almost insoluble in water and in organic solvents, with a particle size of less than 0.1 mm, pH 2 % suspension is 7.1 and 8.7. According to its technological characteristics, this is fine powder of average weight with the average index of flowability. According to its adsorption characteristics, it is a combined meso-macro-microporous adsorbent with a predominance of mesopores, the specific surface is 53.5 m2/g, pore volume – of 0.065 cm3/g, the average pore size of 4.8 nm, adsorption activity by methylene blue – 62.0 mg/g.
Zhilyakova ET, Novikov OO, Malyutina AYu, et al. The development of technology for production and standardization of montmorillonite clay for per os use. Research Result. Medicine and Pharmacy. 2016;2(4):54-65 (In Russian). DOI: 10.18413/2313-8955-2016-2-4-54-65
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