Research Results in Biomedicine
Volume 10, Issue №1, 2024
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Genetics
Retroelements in targeted antitumor therapy (review)
Background: Pathological expression of retroelements is determined in most malignant tumors, which reflects the pathogenesis of tumors, since activated retrotransposons cause genomic instability due to a cascade of mutual ...
Mendelian randomization in eye disorders (review)
Background: Mendelian randomization (MR) is an analytic approach in genetic epidemiology which uses the results of genome-wide association studies (GWAS) to assess causal relationships between various risk ...
Sex-specific features of interlocus interactions determining susceptibility to hypertension
Background: Hypertension (HT) belongs to a group of widespread diseases in both men and women, but at the same time the disease is more often registered (≈20%) in ...
Features of associations of SHBG-related genes with breast cancer in women, depending on the presence of hereditary burden and mutations in the BRCA1/CHEK2 genes
Background: One of the most common diseases of the female population is breast cancer (BC), which is a hormone-dependent pathology and has a significant hereditary component. Candidate ...
Pharmacology
Targeting the Bap1 protein of Vibrio cholerae for screening potent inhibitors and predicting the mutant protein stability: in silico analyses
Background: Bap1 is reported to be a major protein in Vibrio cholerae which aids in biofilm formation. Hence, inhibition of the protein molecule can no longer support the ...
Morphological changes in gum tissue during thiram intoxication followed by correction with resveratrol and sea buckthorn oil
Background: The widespread use of pesticides can lead to a violation of the ecological balance between the environment and the human body, provoking the development of oxidative ...
Medicine (miscellaneous)
Features of geriatric status in patients with arterial hypertension and coronary heart disease (review)
Background: Among the geriatric syndromes associated with the pathology of the cardiovascular system, in particular arterial hypertension (AH) and coronary heart disease as one of the causes ...
The role of negative childhood experiences and internal stigma in the formation of motivation for the treatment of patients with mental disorders
Background: Motivation for treatment is an important component of patients' compliance to treatment of mental disorders, and its formation can be affected by different factors. The aim of ...
The molecular profile people of different ages in «normal» and with dilated cardiomyopathy
Background: Dilated cardiomyopathy (DCMP) is a cardiovascular pathology promising for consideration as a clinical model of premature aging of the body. According to the literature, sirtuins-1, 2, ...
The effect of interleukin-10 gene polymorphism in the formation of deep disorders of vaginal microbiocenosis in bacterial vaginosis
Background: Bacterial vaginosis (BV) is a common vaginal infection that causes significant gynecological and obstetric morbidity. Despite modern methods and treatment regimens, BV therapy remains a difficult ...
