Research Results in Biomedicine
Volume 11, Issue №4, 2025
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Genetics
Common CNVs modulate phenotypes in neurodevelopmental disorders (autism and intellectual disability): focus on SHANK3 and CHAMP1
Background: Common copy number variations (CNVs) are rarely considered as causative in genomic research dedicated to uncovering mechanisms of neurodevelopmental diseases. However, analyzing complex systems of interactions ...
Frequency, spectrum, and functional significance of mutations in the MIR-142 gene in diffuse large B-cell cell lymphoma
Background: MIR-142 is the only human microRNA gene that is highly mutated in diffuse large B-cell lymphoma (DLBCL). Early studies of abnormalities in this gene were based on ...
The relationship between the genetic determinants of SHBG and the hormonal profile of patients with uterine fibroids
Background: Uterine fibroids are benign hormone-dependent tumors that affect the muscle layer of the uterus and are common in women of reproductive age. Genetic factors are important ...
Pharmacology
Chemical composition and antimicrobial activities of Boesenbergia xiphostachya
Background: Boesenbergia xiphostachya is a rare species, recently discovered in Vietnam. Information about the chemical compositions and biological properties of distinct parts of this plant ...
An investigation into the acute and sub-chronic toxicityof ethanol extract of Ardisia sylvestris Pitard leaves in vivo
Background: The global rise in the usage of herbal medicine has prompted a critical examination of its safety. Despite widespread assumptions of safety, there remains a need for ...
Development of Novel Antimicrobial Peptides Targeting Antibiotic-Resistant Pseudomonas aeruginosa
Background: Antibiotic resistance is a global health threat, especially with pathogens like Pseudomonas aeruginosa, which displays high resistance to many antibiotics. Innovative solutions, such as antimicrobial peptides ...
Experimental model of Alzheimer's disease caused by intrahippocampal injection of sodium azide. Comparability with the amyloid model
Background: The treatment of Alzheimer's disease is currently a complex medical task, requiring constant research and development of new medicines. This raises the question of choosing a relevant ...
Medicine (miscellaneous)
The role of mental disorders in the pathogenesis of atopic dermatitis (review)
Background: The problem of atopic dermatitis has received significant attention from researchers across different fields over the years. Despite its high prevalence, there remains an incomplete understanding ...
Effect of cytokine gene polymorphisms on the risk of preeclampsia
Background: Preeclampsia is a multisystem disorder based on placental and endothelial dysfunction, leading to hypertension and other damage to organs and systems during pregnancy and is the leading ...
Age-related resilience in critical periods of life of patients with visual deficits and injuries
Background: Visual impairment and injuries in patients are common in older groups and their prevalence will increase as they age. At the same time, visual deficits and ...
