Pharmacology
Pharmacological correction of metabolic disturbances in experimental acute pancreatitis on the background of chronic alcohol intoxication
Volume 4, Issue №4, 2018
Background: Acute pancreatitis ranks third among all acute surgical diseases of the abdominal cavity and is one of the important unresolved problems in emergency surgery. The aim of the ...
Development of the composition and analysis of suppositories of antihemorrhoidal action
Volume 4, Issue №4, 2018
Background: The study is devoted to the development of composition and assessment of the quality of two-layered suppositories with an oil extract of rowanberries (Sorbus aucuparia) ...
APPROACHES TO CORRECTION OF ISCHEMIC AND REPERFUSION KIDNEY INJURIES IN EXPERIMENT
Volume 4, Issue №3, 2018
Background: Acute kidney injury is an urgent health problem at the junction of specialties with a high level of disability and mortality of patients. The pertinence of the ...
THE PROBLEM OF EXPERIMENTAL MODEL CHOICE IN BIOMEDICAL RESEARCHES OF IMPLANTS (REVIEW)
Volume 4, Issue №3, 2018
Background: Biomedical researches and improvement of methods for medical materials manufacturing with certain properties and their pharmacological support caused the integration of achievements in materials science and medicine and ...
EVALUATION OF ANTIHYPOXIC ACTIVITY OF ETHYLMETHYLHYDROXIPYRIDINE SUKCINATE IN IN VITRO EXPERIMENTS
Volume 4, Issue №3, 2018
Background: The search for potential cardio- and cerebroprotective agents among the derivatives of oxypyridine is topical, since they are proven to contain the compounds with antihypoxic, antioxidant activity, and ...
SIMULATION OF TOTAL BRAIN ISCHEMIA IN RATS
Volume 1, Issue №4, 2015
This paper deals with the study of the dependence of psycho neurological deficit in rats on the severity of brain damage, conducted on the four-vascular models of total cerebral ischemia. ...
THE ROLE OF MITOCHONDRIAL ATP-DEPENDENT POTASSIUM CHANNELS IN THE CARDIOPROTECTIVE EFFECT OF NICORANDIL ON THE MODEL OF CORONARY OCCLUSIVE MYOCARDIAL INFARCTION
Volume 1, Issue №4, 2015
The paper presents the results of a study of the antiischemic effectiveness of nicorandil (1,8 mg/kg) on the model of coronary occlusive myocardial infarction in rabbits. The coronary occlusion in ...
ENDOTHELIO-AND CARDIOPROTECTIVE EFFECTS OF HMG-Co-A REDUCTASE IN ENDOTOKSIN-INDUCING ENDOTELIAL DYSFUNCTION
Volume 1, Issue №4, 2015
The use of inhibitors of HMG-Co-A reductase inhibitor Simvastatin, Atorvastatin, Rosuvastatin and nanoparticulated Rosuvastatin on the background modeling of endotoxin-induced pathology through introduction of strain 603 Staphylococcusaureus leads to the ...
CORRECTION OF ADMA-INDUCED PREECLAMPSIA WITH THE USE OF PHOSPHODIESTERASE 5 AND SELECTIVE INHIBITOR OF ARGINASE II ZB49-0010
Volume 1, Issue №4, 2015
Simulation experimental ADMA-like preeclampsia was carried out by administering the rats with L-NAME during 14-20 days of pregnancy. In animals, there was an increase in blood pressure, proteinuria, impaired microcirculation ...
PHARMACOLOGICAL PRECONDITIONING WITH NICORANDIL AS A POSSIBILITY OF INCREASING THE STABILITY OF TISSUES OF THE RETINA TO ISCHEMIA IN AN EXPERIMENT
Volume 1, Issue №4, 2015
In laboratory rats, we formed an ischemic damage by providing mechanical pressure (110 mm Hg) to the anterior chamber for 30 minutes. The experiment has revealed the fact that nicorandil ...
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