Pharmacology
Effects of first-line anti-TB drugs on the level of toxic plasma phospholipids
Volume 6, Issue №4, 2020
Background: The target of any toxic effect of anti-tuberculosis chemotherapy is primarily the cell. Changes in the structure and functions of cells affect the lipid composition of their membranes ...
The final results of the ASSA-II study: the knowledge of therapeutic doctors on the subject of bronchial asthma
Volume 6, Issue №3, 2020
Background: Bronchial asthma (BA) is one of the leading and socially significant diseases of the respiratory system. In recent years, the proportion of this disease has been steadily ...
Investigation of cerebroprotective properties of the drug «Mexidol» on the model of pneumococcal bacterial meningitis in experimental conditions
Volume 6, Issue №3, 2020
Background: Pneumococcal meningitis is a severe infectious disease, which is characterized by high mortality and frequent development of residual neurological damage. Effective cerebroprotection can improve the outcome of ...
Exhaled nitric oxide as a predictor of the effectiveness of basic therapy for bronchial asthma in children
Volume 6, Issue №2, 2020
Background: The article discusses the predictive ability of monitoring nitric oxide in exhaled air relative to the level of control and the likelihood of developing exacerbations of bronchial ...
Modern possibilities of using the release-active drug Tenoten for Children in the clinical practice of autonomic disorders in children
Volume 6, Issue №2, 2020
Background: Among the pathological conditions found in children and adolescents, vegetative disorders occupy one of the leading places. The development of autonomic dysfunction is due to an imbalance ...
A study of neuroprotective properties of the MGLUR4 receptor agonist – ZC64-0001 in comparison with Mexidol
Volume 6, Issue №2, 2020
Background: One of the most common neurodegenerative diseases is Parkinson's disease, which is based on the degeneration of dopaminergic neurons of the substantia nigra. The modern treatment for Parkinson's ...
Comprehensive assessment of using micronised purified flavonoid fraction in the correction of disorders associated with ADMA-like preeclampsia in experiment
Volume 6, Issue №1, 2020
Background: About 10% of pregnancies in the world are accompanied by hypertensive disorders, while from 2 to 8% are preeclampsia. One of the components of the pathogenesis of preeclampsia is ...
Pharmacological effects of the combined administration of a small dose of Acetylsalicylic acid and methyldopa in ADMA-like preeclampsia
Volume 6, Issue №1, 2020
Background: Hypertensive disorders, in particular preeclampsia, which accounts for 2 to 8% of the total number of pregnancies in the world, are one of the leading causes of ...
Feasibility study of the eye drops composition with vitamins for the treatment of allergic conjunctivitis
Volume 5, Issue №4, 2019
Background: Today, quite a lot of people suffer from allergic conjunctivitis, despite the sufficient market of monocomponent medicines, there is a shortage of combined medicines based on modern substances ...
A comparative analysis of physicians’ basic knowledge with different work experience in the treatment of community-acquired pneumonia. Project «КnoCAP», II phase (2017-2019)
Volume 5, Issue №4, 2019
Background: Community-acquired pneumonia (CAP) is an acute infectious inflammatory disease more often of bacterial etiology that occurs in outside hospital settings. This pathology is an important medical and ...
The study of neurodynamic disturbances in rats with cranial injury
Volume 5, Issue №3, 2019
Background: Domestic and occupational injuries, including traumatic brain injury (TBI), are diseases that are a major public health problem in all industrialized countries and result in incapacitation, as well ...
Determination of the antioxidant activity of the infusion of common sorrel herba in vitro
Volume 5, Issue №3, 2019
Background: Common sorrel (Rumex acetosa L.), a plant from the buckwheat family, is promising for introduction into medicine. Phytochemical studies of common sorrel herba showed that the raw material ...
The study of adaptogenic activity and toxicological safety of the Nigella damascena seed fatty oil extract
Volume 5, Issue №3, 2019
Background: Nigella damascena L. is a plant, extracts from which are characterized by a multicomponent composition of biologically active substances, which have an extensive spectrum of pharmacological properties. In this ...
Practical aspects of the analysis of pharmaceutical substances by the indicator «bacterial endotoxins»
Volume 5, Issue №2, 2019
Background: Safety is one of the basic medicine requirements. «Bacterial endotoxins» is the most important safety indicator of parenteral drug products, ensuring their proper quality. The use of the ...
Correction of ischemic and reperfusion damage in the retina by using imidazoline receptors agonists of types I, II in rats
Volume 5, Issue №2, 2019
Background: The authors note that special literature does not make mention of drugs for targeted, specific correction of retinal ischemia. That is why the study of the possibilities of ...
Development of the composition, production technology, biological studies of medicinal syrup with ethylmethylhydroxypyridine succinate for the prevention and treatment of hypoxic conditions
Volume 5, Issue №2, 2019
Background: Both the dosage form and the complex of auxiliary substances are important pharmaceutical factors determining the final pharmacological effect. It is important to carefully select different groups of ...
Pharmacological correction of immune and metabolic disorders in acute biliary pancreatitis of varying severity
Volume 5, Issue №1, 2019
Background: The incidence of acute pancreatitis is up to 40 cases per 100,000 adult population per year, including about 10-15% of patients with severe forms of this disease, ...
Research on the expansion of the use of extracts of Rhodiola rosea, Linden cordate and Astragalus aspercentage in clinical practice
Volume 5, Issue №1, 2019
Background: One of the problems of modern medicine is to ensure the prevention of a number of diseases caused by a lack of trace elements in the human body, ...
Comparative evaluation of the effectiveness of DMAE derivative 7-16, carbamilated darbepoetin and substance C7070 in correction of hypertensive neuroretinopathy in rats
Volume 5, Issue №1, 2019
Background: Increasing the effectiveness of drug therapy for hyperintensive neuroretinopathy is one of the important tasks of pharmacology and ophthalmology. The aim of the study: To assess the effectiveness of DMAE ...
Perspective materials for drug delivery in the ophthalmic dosage form: a short review of polymers for electrospinning
Volume 4, Issue №4, 2018
Background: The traditional ophthalmological dosage forms have a low bioavailability, a rapid precorneal clearance and a low corneal permeability. The gelling system or system with a prolonged action (prolonged ...
