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Pharmacology

Practical aspects of the analysis of pharmaceutical substances by the indicator «bacterial endotoxins»

Volume 5, Issue №2, 2019
Background: Safety is one of the basic medicine requirements. «Bacterial endotoxins» is the most important safety indicator of parenteral drug products, ensuring their proper quality. The use of the ...

Correction of ischemic and reperfusion damage in the retina by using imidazoline receptors agonists of types I, II in rats

Volume 5, Issue №2, 2019
Background: The authors note that special literature does not make mention of drugs for targeted, specific correction of retinal ischemia. That is why the study of the possibilities of ...

Pharmacological correction of immune and metabolic disorders in acute biliary pancreatitis of varying severity

Volume 5, Issue №1, 2019
Background: The incidence of acute pancreatitis is up to 40 cases per 100,000 adult population per year, including about 10-15% of patients with severe forms of this disease, ...

Comparative evaluation of the effectiveness of DMAE derivative 7-16, carbamilated darbepoetin and substance C7070 in correction of hypertensive neuroretinopathy in rats

Volume 5, Issue №1, 2019
Background: Increasing the effectiveness of drug therapy for hyperintensive neuroretinopathy is one of the important tasks of pharmacology and ophthalmology. The aim of the study: To assess the effectiveness of DMAE ...

Perspective materials for drug delivery in the ophthalmic dosage form: a short review of polymers for electrospinning

Volume 4, Issue №4, 2018
Background: The traditional ophthalmological dosage forms have a low bioavailability, a rapid precorneal clearance and a low corneal permeability. The gelling system or system with a prolonged action (prolonged ...

Development of the composition and analysis of suppositories of antihemorrhoidal action

Volume 4, Issue №4, 2018
Background: The study is devoted to the development of composition and assessment of the quality of two-layered suppositories with an oil extract of rowanberries (Sorbus aucuparia) ...

Pharmacological correction of metabolic disturbances in experimental acute pancreatitis on the background of chronic alcohol intoxication

Volume 4, Issue №4, 2018
Background: Acute pancreatitis ranks third among all acute surgical diseases of the abdominal cavity and is one of the important unresolved problems in emergency surgery. The aim of the ...

THE PROBLEM OF EXPERIMENTAL MODEL CHOICE IN BIOMEDICAL RESEARCHES OF IMPLANTS (REVIEW)

Volume 4, Issue №3, 2018
Background: Biomedical researches and improvement of methods for medical materials manufacturing with certain properties and their pharmacological support caused the integration of achievements in materials science and medicine and ...

EVALUATION OF ANTIHYPOXIC ACTIVITY OF ETHYLMETHYLHYDROXIPYRIDINE SUKCINATE IN IN VITRO EXPERIMENTS

Volume 4, Issue №3, 2018
Background: The search for potential cardio- and cerebroprotective agents among the derivatives of oxypyridine is topical, since they are proven to contain the compounds with antihypoxic, antioxidant activity, and ...

APPROACHES TO CORRECTION OF ISCHEMIC AND REPERFUSION KIDNEY INJURIES IN EXPERIMENT

Volume 4, Issue №3, 2018
Background: Acute kidney injury is an urgent health problem at the junction of specialties with a high level of disability and mortality of patients. The pertinence of the ...

THE ROLE OF MITOCHONDRIAL ATP-DEPENDENT POTASSIUM CHANNELS IN THE CARDIOPROTECTIVE EFFECT OF NICORANDIL ON THE MODEL OF CORONARY OCCLUSIVE MYOCARDIAL INFARCTION

Volume 1, Issue №4, 2015
The paper presents the results of a study of the antiischemic effectiveness of nicorandil (1,8 mg/kg) on the model of coronary occlusive myocardial infarction in rabbits. The coronary occlusion in ...

CORRECTION OF ADMA-INDUCED PREECLAMPSIA WITH THE USE OF PHOSPHODIESTERASE 5 AND SELECTIVE INHIBITOR OF ARGINASE II ZB49-0010

Volume 1, Issue №4, 2015
Simulation experimental ADMA-like preeclampsia was carried out by administering the rats with L-NAME during 14-20 days of pregnancy. In animals, there was an increase in blood pressure, proteinuria, impaired microcirculation ...

ENDOTHELIO-AND CARDIOPROTECTIVE EFFECTS OF HMG-Co-A REDUCTASE IN ENDOTOKSIN-INDUCING ENDOTELIAL DYSFUNCTION

Volume 1, Issue №4, 2015
The use of inhibitors of HMG-Co-A reductase inhibitor Simvastatin, Atorvastatin, Rosuvastatin and nanoparticulated Rosuvastatin on the background modeling of endotoxin-induced pathology through introduction of strain 603 Staphylococcusaureus leads to the ...

PHARMACOLOGICAL PRECONDITIONING WITH NICORANDIL AS A POSSIBILITY OF INCREASING THE STABILITY OF TISSUES OF THE RETINA TO ISCHEMIA IN AN EXPERIMENT

Volume 1, Issue №4, 2015
In laboratory rats, we formed an ischemic damage by providing mechanical pressure (110 mm Hg) to the anterior chamber for 30 minutes. The experiment has revealed the fact that nicorandil ...

SIMULATION OF TOTAL BRAIN ISCHEMIA IN RATS

Volume 1, Issue №4, 2015
This paper deals with the study of the dependence of psycho neurological deficit in rats on the severity of brain damage, conducted on the four-vascular models of total cerebral ischemia. ...
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