Pharmacology
CORRECTION OF ADMA-INDUCED PREECLAMPSIA WITH THE USE OF PHOSPHODIESTERASE 5 AND SELECTIVE INHIBITOR OF ARGINASE II ZB49-0010
Volume 1, Issue №4, 2015
Simulation experimental ADMA-like preeclampsia was carried out by administering the rats with L-NAME during 14-20 days of pregnancy. In animals, there was an increase in blood pressure, proteinuria, impaired microcirculation ...
PHARMACOLOGICAL PRECONDITIONING WITH NICORANDIL AS A POSSIBILITY OF INCREASING THE STABILITY OF TISSUES OF THE RETINA TO ISCHEMIA IN AN EXPERIMENT
Volume 1, Issue №4, 2015
In laboratory rats, we formed an ischemic damage by providing mechanical pressure (110 mm Hg) to the anterior chamber for 30 minutes. The experiment has revealed the fact that nicorandil ...
ENDOTHELIO-AND CARDIOPROTECTIVE EFFECTS OF HMG-Co-A REDUCTASE IN ENDOTOKSIN-INDUCING ENDOTELIAL DYSFUNCTION
Volume 1, Issue №4, 2015
The use of inhibitors of HMG-Co-A reductase inhibitor Simvastatin, Atorvastatin, Rosuvastatin and nanoparticulated Rosuvastatin on the background modeling of endotoxin-induced pathology through introduction of strain 603 Staphylococcusaureus leads to the ...
THE ROLE OF MITOCHONDRIAL ATP-DEPENDENT POTASSIUM CHANNELS IN THE CARDIOPROTECTIVE EFFECT OF NICORANDIL ON THE MODEL OF CORONARY OCCLUSIVE MYOCARDIAL INFARCTION
Volume 1, Issue №4, 2015
The paper presents the results of a study of the antiischemic effectiveness of nicorandil (1,8 mg/kg) on the model of coronary occlusive myocardial infarction in rabbits. The coronary occlusion in ...
SIMULATION OF TOTAL BRAIN ISCHEMIA IN RATS
Volume 1, Issue №4, 2015
This paper deals with the study of the dependence of psycho neurological deficit in rats on the severity of brain damage, conducted on the four-vascular models of total cerebral ischemia. ...
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