Association of the ITGB3 gene T1565C polymorphism with the development of atherosclerosis and in-stent restenosis in patients with stable coronary artery disease
Background: Today, percutaneous coronary intervention (PCI) is the most effective treatment of coronary artery disease (CAD). Despite all technical advances in stent designs and techniques, in-stent restenosis (ISR) remains one of the main limiting factors of this procedure. Studies in the field of molecular cardiology have shown a significant contribution of endothelial dysfunction in the development of ISR. According to the literature, integrin beta 3 is involved in intercellular interactions, interaction with extracellular matrix; it influences the activity of smooth muscle cells, which can lead to neointimal hyperplasia. The aim of the study: To study the possibility of association of T1565C polymorphism of the ITGB3 gene with the development of restenosis after stenting of the coronary arteries. Materials and methods: Patients with CAD after PCI with drug-coated stents (n = 110) and patients with intact vessels according to angiography (n = 62) were included in the study. The repeated stenosis of the artery at the stent implantation site of more than 50% was defined as angiographic restenosis. The criteria for inclusion in the study were: age > 45 years, ethnic Russians, atherosclerosis according to the angiography of one or more arteries, patient informed consent. The genotyping for the ITGB3 T1565C polymorphism was performed using the real-time PCR. Results: The C allele and heterozygous genotype frequencies are significantly higher in groups of patients with earlier development of restenosis and diffuse CAD with occlusion. Conclusion: The minor C allele of the ITGB3 T1565C polymorphism may be considered as a predictor of diffuse CAD with the development of occlusions and ISR of the coronary arteries within the first year after stent implantation.
Bogatyreva KB, Azova MM, Aghajanyan AV, et al. Association of the ITGB3 gene T1565C polymorphism with the development of atherosclerosis and in-stent restenosis in patients with stable coronary artery disease. Research Results in Biomedicine. 2018;4(4):3-9 (In Russian). DOI: 10.18413/2313-8955-2018-4-4-0-1
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