Features of gene control of blood pressure in patients with hypertensive disorders during pregnancy
Background: Chronic arterial hypertension and preeclampsia are multifactorial pathologies, in the development of which many groups of genes are involved in combination with negative environmental influence. The aim of the study: To study molecular genetic markers of an increased risk of developing hypertensive disorders during pregnancy will make it possible to timely form a risk group for early prevention of possible complications. Materials and methods: A study of the polymorphism of genes controlling vascular wall tone was performed using real-time polymerase chain reaction in 49 patients, who were pregnant against the background of chronic arterial hypertension, and 42 women with chronic arterial hypertension and preeclampsia. Results: AGT 704C, CYP11B2 C(-344)T, GNB3 825T/Т variants were shown in patients with chronic arterial hypertension and joined preeclampsia in the genotype significantly more often than in women with chronic arterial hypertension. Conclusion: The presence of these negative polymorphisms in the genotype of a pregnant woman is combined with resistance to a single-component antihypertensive therapy, which requires the appointment of a combined treatment regimen for this category of patients to achieve the target blood pressure level.
Fetisova IN, Malyshkina AI, Panova IA, et al. Features of gene control of blood pressure in patients with hypertensive disorders during pregnancy. Research Results in Biomedicine. 2021;7(1):56-66. Russian. DOI: 10.18413/2658-6533-2020-7-1-0-5
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