PHARMACOLOGICAL PRECONDITIONING WITH NICORANDIL AS A POSSIBILITY OF INCREASING THE STABILITY OF TISSUES OF THE RETINA TO ISCHEMIA IN AN EXPERIMENT
In laboratory rats, we formed an ischemic damage by providing mechanical pressure (110 mm Hg) to the anterior chamber for 30 minutes. The experiment has revealed the fact that nicorandil (0.6 mg/kg) prevents the development of degenerative changes in the retinal layers induced by ischemic injury. The severity of the protective effect of nicorandil on the retina of the rats was assessed after 72 hours of reperfusion after modeling the pathology. We have found a protective effect of nicorandil with the development of ischemia, which was confirmed by the laser Doppler flowmetry and histomorphometry. The identification and application of pharmacological agents with the effect of preconditioning may be a novel approach in the correction and prevention of ischemia of the retina which is the leading element in the pathogenesis of a number of eye pathologies. The possibility of pharmacological preconditioning with nicorandil of ischemic damage to the retina is essential for the development of anti-ischemic agents for the treatment and prevention of ophthalmic pathologies of an ischemic genesis.
Denisyuk TA. Pharmacological preconditioning with nicorandil as a possibility of increasing the stability of tissues of the retina to ischemia in an experiment. Research Result. Medicine and Pharmacy Series. 2015;1(4):74-78 (In Russian). DOI: 10.18413 / 2313-8955-2015-1-4-74-78
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