Research Results in Biomedicine
Volume 11, Issue №1, 2025
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Genetics
Pathway directed mechanisms of anti-EGFR resistance in colorectal cancer (review)
Background: Targeting the epidermal growth factor receptor (EGFR) with cetuximab or panitumumab (anti-EGFR MAb) has been historically reserved for patients with RAS/BRAF wild-type advanced colorectal cancer (CRC). However, ...
Relationship of transposable elements with non-coding RNAs in the development of atherosclerosis (review)
Background: Atherosclerosis is the leading cause of cardiovascular pathology in adults around the world. Association of the disease with age indicates the presence of common mechanisms for ...
Association of polymorphic locus rs4880 of superoxide dismutase 2 gene (SOD2) with Polycystic Ovary Syndrome: A meta-analysis
Background: According to WHO, approximately 8-13% of women of reproductive age suffer from polycystic ovary syndrome (PCOS), while up to 70% of women worldwide with PCOS remain ...
Genetic variants of sex hormone-binding globulin and hormonal profile in patients with genital endometriosis
Background: Endometriosis is a chronic inflammatory, dyshormonal disease. Genetic factors play an important role in its development. Sex hormone imbalance is important for the occurrence, growth and ...
Pharmacology
Spectrum of anti-inflammatory, anti-infectious and anti-tumor activity of quinazoline and quinazolinone derivatives (review)
Background: A new class of medicinal compounds – derivatives of quinazoline and quinazolinone have been actively studied in recent years, on their basis drugs with polyvalent influence ...
Bioactivity of Vitamin D and Tinospora cordifolia Extract in Increasing Cathelicidin Synthesis and Regulating TNF Alpha Production in CD66a Cells
Background: Cathelicidin is an antimicrobial peptide that plays an important function in the innate immune system as the first line of defense against infections. There is still ...
Medicine (miscellaneous)
The use of Zebrafish (Danio rerio) as model subjects for the study of age-associated diseases (review)
Background: Ageing is an evolutionary long-term biological process that leads to a decline in the functional capacity of the human body. As the number of elderly people ...
Regulation of natural killer cells cytotoxicity by trophoblast cells: proteins and receptors
Background: Interaction between trophoblast and natural killer cells is determined by microenvironment. Cytotoxicity of NK against targets, including trophoblasts, is associated with production of perforin, granzymes. Trophoblasts are ...
Features of testing the basic functional activity of patients with sarcopenic obesity and visual impairment
Background: Various functional deficits, including visual deficits, as well as sarcopenic obesity, cause a decrease in activity in the daily life of patients. These deficits are challenging ...
Association of polymorphisms of genes in neurotransmitter systems of the brain with the risk of developing mental disorders in children left without parental care
Background: Social orphans have a variety of behavioural and intellectual disorders. A number of specific polymorphisms in genes involved in the brain's dopamine and serotonin neurotransmitter systems ...
