Research Results in Biomedicine
Volume 12, Issue №1, 2026
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Genetics
Current advances in gene therapy for retinitis pigmentosa using adeno-associated virus (review)
Background: Retinitis pigmentosa is a group of inherited retinal disorders characterized by progressive degeneration of photoreceptors and the retinal pigment epithelium. This leads to irreversible vision loss, ...
Investigation of NFKB1 Gene Expression and rs28362491 Polymorphism in Relation to Diabetic Nephropathy and Glycemic Dysregulation in Iraqi T2DM Patients
Background: Diabetic nephropathy is a microvascular complication that can occur in people type 2 diabetes nephropathy (T2DN). The aim of the study: To investigate the correlation between ...
The missense variant rs11556924 in ZC3HC1 has a protective effect against the risk of peripheral artery disease in women
Background: Peripheral artery disease (PAD) is one of the most common forms of diseases of the peripheral vessels of the lower extremities. Taking into account the potential ...
Pharmacology
Neisseria gonorrhoeae LOS Decreased NF-ĸB and IRF3 Expression but Had No Effect in IFN-β Expression and HIV Replication on Naïve-HIV Lymphocytes
Background: Neisseria gonorrhoeae (N. gonorrhoeae) is a gram-negative bacterium with a lipooligosaccharides (LOS)-based cell membrane. LOS is considered to supress HIV-1 replication by downregulating NF-κB, IRF3, and ...
Evaluation of efficacy of selective phenolic compounds of olive leaves in chronic myeloid leukemia: an in-silico approach
Background: Chronic myeloid leukemia (CML) is a blood cancer driven by the BCR-ABL1 fusion protein, where current therapies face challenges like resistance and side effects. Olive leaves ...
Mitigation of indomethacin-induced gastric inflammation in mice through the administration of ethanol extract from Hedyotis capitellata Wall. leaves
Background: Gastritis, a prevalent global malady, stems from various factors such as unhealthy lifestyles, bacterial infections, or non-steroidal anti-inflammatory drug usage. If untreated, it leads to severe complications. ...
Antiarrhythmic effect of amiodarone on epinephrine-induced ventricular arrhythmias in rats with experimental hyperglycemia and its combination with hypercholesterolemia
Background: Amiodarone, a class III antiarrhythmic agent, has been shown to be effective against epinephrine-induced ventricular arrhythmias in metabolically neutral animals. However, its effectiveness in models of ...
Medicine (miscellaneous)
Artificial intelligence models in cardiotocography (review)
Background: Fetal hypoxia is a pathological state characterized by insufficient oxygen supply to the human fetal tissue. Oxygen deficiency causes a cascade of pathological complications, including decompensation, ...
Age-related diagnostic and deficiency features patients with metabolic-associated fatty liver disease
Background: Due to the growing elderly population and persistent nutritional misconceptions, the prevalence of metabolic-associated fatty liver disease (MAFLD) is rising. This condition can further worsen the ...
Validation of the Russian version of the Recovery Assessment Scale – Domains and Stages (RAS-DS) to assess recovery after the first psychotic episode
Background: This scientific article is significant due to the lack of Russian-language psychometric scales that can objectively assess the parameters of personal recovery within the broader concept of ...
