Research Results in Biomedicine
Volume 8, Issue №2, 2022
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Genetics
Association of polymorphism rs10841855 in the glycogen synthase 2 gene with hypercholesterolemia and type 2 diabetes mellitus
Background: Glycogen synthase 2 (GYS2) catalyzes a key step in glycogenesis in the liver. Loss-of-function mutations in the GYS2 gene are associated with type 0a glycogenosis with characteristic fasting ...
The association of inflammatory status and immunological parameters with single-nucleotide polymorphisms of cytokine and Toll-like receptor genes in patients with schizophrenia
Background: Schizophrenia is a multifactorial and clinically polymorphic disease with a significant hereditary component. The study of the influence of functionally significant polymorphisms of the genes regulating immune response ...
Germline mutations as possible biomarkers of immune checkpoint inhibitor therapy efficacy in patients with renal cell carcinoma (mini review)
Background: The use of immune checkpoint inhibitors (ICIs) is a promising therapy in cancer treatment, in particular renal cell carcinoma (RCC). Despite the revolutionary breakthrough in cancer treatment, a ...
The role of highly penetrant mutations in BRCA1 and CHEK2 genes in the pattern of associations of matrix metalloproteinase gene polymorphisms with breast cancer
Background: Breast cancer (BC) is a malignant breast tumor, which occupies a leading place both in the structure of oncological diseases in women and among the causes of female ...
Pharmacology
Pharmacological characteristics of intranasal dosage forms containing Ginkgo biloba extracts
Background: This article reviews the pharmacological characteristics of developed dosage forms for intranasal administration. The influence of the type of dosage form on the efficacy of the drug ...
Status of the glutathione antioxidant defense in fungicide intoxication and correction with vitamin A and milk thistle
Background: Thiram entering with food products into tissues and organs of animals and humans can lead to the activation of free-radical oxidation processes and, as a consequence, imbalance in ...
Medicine (miscellaneous)
Correlation of Biochemical Abnormalities with the Severity of Hospitalized Covid-19 Patients
Background: Coronavirus Disease-19 (COVID-19) has a global impact. The laboratory assessments in Covid-19 illness help in better understanding the disease pathophysiology useful in screening asymptomatic individuals to diagnosis, prognosis and ...
Comparative analysis of sleep quality in healthy girls and women during gestation
Background: Sleep disorders during pregnancy pose a real threat to the mother and fetus due to a violation of the physiological course of the gestation process, the release of ...
Characteristics of nutrition in elderly people with adentia: geriatric and dietary aspects
Background: To date, many evidence-based studies have provided data that give insight into the clear relationship between the severity of adentia as a manifestation of age-related oral syndrome and ...
Peculiarities of postural disorders and connections with the blood compliment system in the case of falls syndrome in the elderly
Background: Natural and premature aging is accompanied by postural disorders, which are aggravated in patients with ophthalmic pathology and lead to the occurrence of the falls syndrome, but remain insufficiently ...
