Research Results in Biomedicine
Volume 11, Issue №3, 2025
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Genetics
Associations of the 786T>C (rs2070744) polymorphism of the NOS3 gene with main somatometric indices and cardiovascular system characteristics in the age aspect in northern men
Background: A lack of information regarding the association between NOS3 gene polymorphism variants and age-related changes in basic somatometric characteristics and the circulatory system prevents us from ...
Effect of the COVID-19 pandemic on the frequency and spectrum of chromosomal abnormalities in abortions in early pregnancy failure
Background: The adverse effects of COVID-19 have affected the condition of various human organs and systems, including the reproductive system; in this regard, the assessment of the ...
Seipinopathies: clinical variants of hereditary motor-sensory neuropathy and spastic paraplegia caused by mutations in the BSCL2 gene in patients from the Volga-Ural region
Background: Neuronal forms of seipinopathies are rare pathologies and are mainly caused by two pathogenic variants of the BSCL2 gene, p.269C>T (p.Ser90Leu) and p.263A>G (p.Asn88Ser). Incomplete penetrance and ...
Pharmacology
Review of clinical trials of promising bispecific candidates for CAR-T cell therapy
Background: CAR-T (Chimeric Antigen Receptor T-Cell) therapy has proven to be highly effective in the treatment of oncohematological diseases. In pivotal clinical trials for CD19-positive tumors (ZUMA-1, ...
Exploring the Medicinal Potential of Jatropha gossypifolia Leaf Extract: a Comprehensive Analysis of Bioactive Compounds, Antimicrobial Activities, and Molecular Interactions in the Treatment of Atopic Dermatitis
Background: Jatropha gossypifolia, a plant traditionally recognized for its therapeutic properties, has gained scientific interest due to its potential pharmacological applications. However, comprehensive studies exploring its bioactive constituents ...
Evaluation of the therapeutic effects of fonturacetam in the chronic unpredictable mild stress (CUMS) model in rats
Background: Chronic stress can lead to adverse consequences such as occupational burnout syndrome (OB). Considering the social significance of the disease and the lack of standard treatment, ...
Osteoprotective and regenerative effects of the plant polyphenol resveratrol in postmenopausal osteoporosis: an experimental pharmacological study
Background: Osteoporosis is one of the major metabolic, age-related skeletal diseases and a serious medical and socioeconomic problem worldwide. This is due to its steadily increasing prevalence and ...
Medicine (miscellaneous)
The influence of eating patterns and dietary habits, deficiency of macro- and micronutrients on the reproductive health of women (review)
Background: Russian and international literature increasingly focuses on identifying modifiable environmental, lifestyle, and nutritional risk factors that affect human reproductive function. Furthermore, it is crucial to recognise ...
Effect of sarcopenic obesity and visual deficits on the physical functionality of elderly patients
Background: Sarcopenic obesity and visual deficits represent widespread functional deficits, but despite this, their significance in changing the physical functionality of elderly patients with sarcopenic obesity and ...
Features of the gut microbiome in people with increased anxiety
Background: Anxiety and anxiety disorders are among the most common mental illnesses worldwide. There is increasing evidence that the gut microbiome plays a role in the development ...
