Research Results in Biomedicine

Olga V. Kochetova, Diana Sh. Avsaleydiniva, Gulnaz F. Korytina, Tatiana V. Viktorova

Background: Type 2 diabetes mellitus (T2DM) is an expanding global health problem of the 21st century. There has been a global increase in the number of patients with T2DM. ...

Associations of polymorphic variants of candidate genes with the development of ***H. pylori*-negative duodenal ulcer in residents of the Central Chernozem region of Russia**

Olga V. Rashina

Background: Peptic ulcer disease (PUD) is a chronic recurrent disease that occurs with alternating periods of exacerbation and remission, the leading manifestation of which is the formation of a ...

Outcomes of ROHs (runs of homozygosity)/LCSHs (long contiguous stretches of homozygosity) spanning the imprinted loci of chromosomes 7, 11 and 15 among children with neurodevelopmental disorders

Oksana S. Kurinnaia, Kirill S. Vasin, Maria A. Zelenova, Yuri B. Yurov, Victoria Y. Voinova, Svetlana G. Vorsanova, Ivan Y. Iourov

Background: Runs of homozygosity or long contiguous stretches of homozygosity (ROHs/LCSHs) are common in the human genome. ROHs/LCSHs spanning the imprinted loci have been previously associated with neurodevelopmental disorders. ...

The role of DNA methylation in lung cancer (review)

Aigul R. Nizamova, Galiya F. Gimalova, Elza K. Khusnutdinova

Background: Lung cancer has been a difficult-to-treat disease for decades, despite the efforts of oncologists and pharmaceutical companies. One of the reasons for this is the heterogeneity of the ...

Association between mitochondrial DNA copy number and high viral load in women with high-risk human papillomavirus

Abbas H.H. AlBosale, Elena V. Mashkina

Background: The infection that most often leads to cervical cancer is human papillomavirus (HPV) infection. A sign that the HPV infection might develop into cancer is mitochondrial dysfunction and ...

Mendelian randomization: using genetic information in epidemiological studies (review)

Denis Y. Plotnikov

Background: Mendelian randomization is a research method that exploits the instrumental variable framework using genetic information to assess the causality of the relationship between modifiable risk factors and health ...

A replication study of genetic variants associated with high-level musical aptitude

Anastasiya V. Kazantseva, Renata F. Enikeeva, Alla V. Toropova, Ilya M. Zakharov, Viktoria I. Ismatullina, Elza K. Khusnutdinova, Sergey B. Malykh

Background: Existing genetic studies on musical abilities have focused on various molecular approaches, which determined gene regions/variants implicated in (i) music perception and performance based on genome-wide linkage ...

Genetic markers of knee osteoarthritis in women of the Central Chernozem region of Russia

Vitaly B. Novakov, Olga N. Novakova, Inna N. Sorokina, Irina V. Batlutskaya, Olga A. Efremova, Valentina S. Orlova

Background: Knee osteoarthritis (KO) is a multifactorial disease. Among the many risk factors for the disease, the role of the hereditary component is undeniable. The share of genetic factors ...

**The role of molecular genetic changes in the structure of the CDH1 gene in the development of gastric cancer in patients from the Republic of Bashkortostan**

Alfiya Kh. Nurgalieva, Liliya F. Gallyamova, Ruslan R. Valiev, Sabina G. Petrova, Murat A. Dzhaubermezov, Darya S. Prokofieva, Natalia V. Ekomasova, Radmir R. Rakhimov, Dina D. Sakaeva, Shamil M. Khusnutdinov, Elza K. Khusnutdinova

Background: Gastric cancer (GC) is one of the most serious diseases, occupying a leading position among the causes of death from malignant neoplasms in the world. The Republic of ...

Allelic polymorphism of genes involved in IL-1β production and predisposition of people to the development of arterial hypertension

Ludmila V. Topchieva, Irina V. Kurbatova, Irina E. Malysheva, Viktoria A. Korneva, Anna V. Topchieva

Background: The level of IL-1β in blood plasma is determined not only by pro-inflammatory stimuli, but also by allelic polymorphism of the IL1B and NLRP3 genes. Information on ...

Genetic determinants of sex hormone levels in endometriosis patients

Ilya O. Golovchenko

Background: Endometriosis is a chronic hormone-dependent inflammatory disease determined by the presence of foci of the endometrial tissue outside the uterine cavity. Genetic factors occupy a leading ...

**Polymorphic loci of AC026703.1 and HFE genes are associated with severe hypertension**

Tatyana A. Ivanova

Background: Hypertension (HT) is characterized by high blood pressure (BP) and is one of the most common diseases in the world. At the moment, there is information in the ...

Study of the exosomal microRNA-126 and microRNA-218 expression profiles in patients with hemorrhagic fever with renal syndrome (HFRS)

Irina R. Gilyazova, Guzel M. Khasanova, Elizaveta A. Ivanova, Dilara D. Asadullina, Aliya N. Khasanova, Adel A. Izmailov, Gulshat R. Gilyazova, Guoqing Wang, Honglan Huang, Jiahui Pan, Tong Shao, Haochen Yao, Wenfang Wang, Elza K. Khusnutdinova

Background: Hemorrhagic fever with renal syndrome (HFRS), caused by orthohantaviruses, occupies one of the leading places among natural focal human diseases, for which there are no modern accurate and highly ...

Knock-out of α-, β-, and γ-synuclein genes in mice leads to changes in the distribution of several lipids in the liver and blood plasma

Ekaterina A. Lysikova, Kirill D. Chaprov

Background: In addition to the role of synuclein proteins in synaptic transmission through binding with lipid membranes, the function of synucleins in reactions of the synthesis of lipids and ...

**Association of the rs10508336 polymorphism of the TAF3 transcription factor gene with the risk of lower limb arterial disease in the Russian population**

Sergey N. Zhabin

Background: Atherosclerosis obliterans (AO) and diabetic angiopathy (DA) are known to be peripheral artery diseases (PAD) of multifactorial origin, in which genetic and environmental factors play a synergetic role. ...

Molecular cytogenetic and cytopostgenomic analysis of the human genome