Genetics
EXPRESSION OF TOLL-LIKE RECEPTORS IN THE FEMALE REPRODUCTIVE TRACT AND ITS HORMONE REGULATION (REVIEW)
Volume 4, Issue №3, 2018
Background: Toll-like receptors (TLR) are the main receptors of the innate immune system, recognizing ligands of bacteria, viruses, fungi and protozoa and inducing immune response. However, complex ...
MOLECULAR-GENETIC ANALYSIS OF ASSOCIATIONS OF POLYMORPHOUS GENES COMBINATIONS OF THE XENOBIOTICS BIOTRANSFORMATION WITH THE ISOLATED VENTRICULAR SEPTAL DEFECT DEVELOPMENT IN THE KRASNODAR TERRITORY
Volume 4, Issue №3, 2018
Background: The study of the involvement of polymorphisms of candidate genes of the biotransformation system of xenobiotics in the formation of congenital malformations in children is one of the ...
SELECTION OF POLYMORPHIC LOCI FOR ASSOCIATION ANALYSIS IN GENETIC-EPIDEMIOLOGICAL STUDIES
Volume 4, Issue №2, 2018
Background. The study of the role of hereditary factors in the formation of multifactorial signs is relevant, and in relation to multifactorial diseases, these studies are important for ...
MOLECULAR AND GENETIC CHARACTERISTICS OF PATIENTS WITH HYPERPLASIA AND ENDOMETRIC POLYPS
Volume 4, Issue №2, 2018
Background. Hyperplastic processes of the endometrium (GGE) are among the most frequent gynecological diseases, leading to a loss of reproductive function and a decrease in the quality of life ...
POLYMORPHISM OF IL10, CTLA4 GENES AND PREDISPOSITION TO RHEUMATOID ARTHRITIS
Volume 4, Issue №2, 2018
Background. Rheumatoid arthritis (RA) is a systemic autoimmune disease, accompanied by chronic inflammation of the joints synovial membrane and a wide spectrum of extra-articular manifestations. Today, the problem of ...
BIOMARKERS FOR CHILDHOOD NONMALIGNANT BRAIN DISEASES ASSOCAITED WITH CHROMOSOME INSTABILITY
Volume 4, Issue №2, 2018
Background. Over the past ten years, there has been provided a sufficient amount of data demonstrating that chromosome instability is not limited to being a molecular and cellular mechanism ...
THE ROLE OF POLYMORPHISMS OF GLUTAMATE-CYSTEINE LIGASE IN TYPE 2 DIABETES MELLITUS SUSCEPTIBILITY IN KURSK POPULATION
Volume 4, Issue №1, 2018
Relevance. Glutamate-cysteine ligase (GCL) is the first enzyme of the glutathione cycle, intra- and extracellular antioxidant, whose impaired metabolism plays an important role in type 2 diabetes (T2D) pathogenesis. ...
THE INVOLVEMENT OF GENES OF MATRIX METALLOPROTEINASES IN THE DEVELOPMENT OF ARTEIAL HYPERTENSION AND ITS COMPLICATION (REVIEW)
Volume 4, Issue №1, 2018
Cardiovascular diseases are the leading cause of death and disability in Russia and in the world, and hypertension is considered to be an independent predisposing factor in such ...
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