Research Results in Biomedicine
Volume 12, Issue №2, 2026
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Genetics
Clinical characterization of a child with de novo partial trisomy 9p24-9q12
Background: Partial trisomy 9p is considered the fourth most frequently reported trisomy in live births, following trisomies 21, 18, and 13. This relatively high incidence is observed, ...
Investigation of SNP-SNP interactions of maternal organism in matrix metalloproteinases genes and folate cycle genes and their influence on birth weight
Background: The birth weight is one of the main parameters of the normal course of pregnancy. High/low birth weight is associated with the development of chronic diseases ...
Polymorphisms of the Glutathione S-Transferase Genes GSTA4 and GSTP1 as Markers of Predisposition to Psoriasis and Its Clinical Features
Background: Psoriasis is a chronic immune-mediated disease of multifactorial nature with steadily increasing incidence, reaching 2-4% in the population. Despite the identification of more than 80 susceptibility loci, a ...
Pharmacology
Therapeutic potential of Hsp70 in ALS and other proteinopathies: from molecular mechanisms to gene therapy (review)
Background: Disruption of cellular proteostasis and aggregation of pathological proteins are central components in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Existing ...
Optimization of Naltrexone and Nicotine Co-Delivery via PVP/PVA Microneedle Systems: A Translational Approach
Background: Addiction to alcohol and nicotine remains a global health challenge, with current treatment options often hindered by issues of frequent dosing and low patient adherence. Transdermal drug ...
Pre-treated Enterococcus faecalis with Sub-inhibitory concentrations of Cefepime Modulate Biofilm Formation and Adhesion in vitro
Background: Modifying biofilm formation and adhesion could aid in developing treatments for infectious diseases caused by Enterococcus faecalis, a multidrug-resistant bacteria responsible for urinary tract infections (UTIs). The ...
Phytochemical and pharmacological properties of acetone extract fromCurcuma vitellina
Background: Curcuma vitellina has been recently described as a new species in the flora of Vietnam. To date, it is a rare species and its phytochemical and ...
Medicine (miscellaneous)
The relationship between fibroblast growth factor 21 (FGF-21) and clinical and laboratory parameters in geriatric patients with rheumatoid arthritis
Background: Systemic FGF-21 levels are known to be associated with obesity and inflammatory cytokines, and with reduced functional status in rheumatoid arthritis (RA). It is possible to ...
The prospects of regulating the interaction between NK cells and trophoblast cells through cyclin-dependent kinase inhibitors
Background: Background: Analyzing the interaction between natural killer (NK) cells and trophoblast cells is crucial for understanding reproductive immunology processes and developing innovative therapeutic approaches. This study ...
The influence of maternal deprivation on the level of extracellular dopamine when modeling the state of excitement
Background: Maternal deprivation (MD) in early ontogenesis causes persistent changes in emotional reactions and drug abuse in animals. In the present study, we modeled an addictive state of ...
