16+

Genetics

Study of associations of haplotypes of FLG gene polymorphism with the development of chronic true eczema in men
 

Volume 6, Issue №2, 2020
Background: Eczema is a common chronic disease characterized by inflammation of the skin. The aim of the study: To analyze the involvement of haplotypes of polymorphic loci of ...

The contribution of gene-gene interactions of polymorphic loci of matrix metalloproteinases to susceptibility to primary open-angle glaucoma in men
 

Volume 6, Issue №1, 2020
Background: Primary open-angle glaucoma (POAG) is a serious form of eye diseases leading to blindness and disability. Glaucoma in men occurs in more than half of cases (65%). ...

ZNF804A rs1344706 gene polymorphism and clinical heterogeneity of schizophrenia
 

Volume 6, Issue №1, 2020
Background: Replication of genome-wide association study (GWAS) loci for schizophrenia in different populations as well as the study of their specificity for disease are important issues in searching ...

The role of polymorphic variants of the contactin-associated-like protein-2 (CNTNAP2) gene in the formation of differences in anxiety levels

Volume 6, Issue №1, 2020
Background: The study of the multifactor nature of anxiety is caused by its role in multiple aspects of human development including physical and mental health, emotional sphere and social ...

Contribution of rs11927381 polymorphism of the IGF2BP2 gene to the pathogenesis of type 2 diabetes

Volume 6, Issue №1, 2020
Background: Pancreatic beta-cell dysfunction, along with the insulin resistance of peripheral tissues, is a key element in the pathogenesis of type 2 diabetes (T2D). In this regard, of ...

The study of the association of polymorphic loci of the folate cycle genes with the development of the 2-3-degree fetal growth restriction syndrome
 

Volume 6, Issue №1, 2020
Background: Folate cycle enzymes regulate key reactions in folate-mediated single-carbon metabolism. The folate cycle disturbances may be associated with the occurrence of placental insufficiency with fetal growth restriction ...

New data collection priority: focusing on genome-based bioinformation

Volume 6, Issue №1, 2020
Genetic research used to be data-driven under the framework of well-established gene theory. With the advance of various-omics technologies, large-scale data generation has become routine. However, data analyses ...

The role of interaction of polymorphic loci of the FLG gene in the development of chronic true eczema in women

Volume 5, Issue №4, 2019
Background: Eczema is a multifactorial disease. Its development is determined by the polygenic basis and the action of inciting events of exogenous and endogenous nature. The aim of the ...

Effect of IL10 (rs1800872) and CXCL10 (rs4386624, rs4256246) genes polymorphism in the development of viral and bacterial infectious diseases

Volume 5, Issue №4, 2019
Background: Host-pathogenic interaction is a necessary but not sufficient precondition for the development of the disease. The immune response to the introduction of pathogen is largely controlled by genetic ...

A clinical case of Proteus syndrome in an early age child

Volume 5, Issue №3, 2019
Despite the undoubted progress of medical science around the world, recently, there has been a tendency of an increase in the frequency of congenital malformations and hereditary diseases in ...

Search for binding sites for micro RNA in cis-regulatory sequences and in SNP in the lipid, carbohydrate metabolism, oxidative and anti-inflammatory homeostasis genes

Volume 5, Issue №3, 2019
Background: Polymorphisms and disruption of the expression profile of miRNA genes are associated with systemic diseases (autoimmune and cardiovascular diseases). The aim of the study: To study the localization of miRNA ...

The applicability of interphase chromosome-specific multicolor banding (ICS-MCB) for studying neurodevelopmental and neurodegenerative disorders

Volume 5, Issue №3, 2019
Background: Interphase chromosome-specific multicolor banding (ICS-MCB) has been developed for studying whole chromosomes in interphase nuclei at any stage of the cell cycle at molecular resolution. Previously, important biomedical ...

Familial translocation t(5;11)(q32;q23) resulting in Jacobsen syndrome and distal trisomy 5q31 in a female patient

Volume 5, Issue №3, 2019
Background: Jacobsen syndrome is a rare contiguous gene disorder caused by partial deletion of the distal part of the long arm of chromosome 11 (prevalence 1/100,000 live births). Most ...

Analysis of polymorphic gene loci of antioxidant protection enzymes in three ethnic groups of the Republic of Bashkortostan

Volume 5, Issue №2, 2019
Background: The ideal dose of drugs varies widely among patients, mainly due to genetic factors. Introduction to clinical practice of pharmacogenetic testing in a certain region should be preceded ...

Analysis of the association between C936T VEGFA gene polymorphism and diabetic foot syndrome in the Ukrainian population

Volume 5, Issue №2, 2019
Background: The dysfunction of vascular endothelial growth factor A (VEGFA) is one of the leading factors of macro- and microangiopathy development in diabetic foot syndrome (DFS) patients. Recently, a ...
Previous | Page 5 of 6 | Next