Medicine (miscellaneous)
Features of testing the basic functional activity of patients with sarcopenic obesity and visual impairment
Volume 11, Issue №1, 2025
Background: Various functional deficits, including visual deficits, as well as sarcopenic obesity, cause a decrease in activity in the daily life of patients. These deficits are challenging ...
Association of polymorphisms of genes in neurotransmitter systems of the brain with the risk of developing mental disorders in children left without parental care
Volume 11, Issue №1, 2025
Background: Social orphans have a variety of behavioural and intellectual disorders. A number of specific polymorphisms in genes involved in the brain's dopamine and serotonin neurotransmitter systems ...
Regulation of natural killer cells cytotoxicity by trophoblast cells: proteins and receptors
Volume 11, Issue №1, 2025
Background: Interaction between trophoblast and natural killer cells is determined by microenvironment. Cytotoxicity of NK against targets, including trophoblasts, is associated with production of perforin, granzymes. Trophoblasts are ...
The use of Zebrafish (Danio rerio) as model subjects for the study of age-associated diseases (review)
Volume 11, Issue №1, 2025
Background: Ageing is an evolutionary long-term biological process that leads to a decline in the functional capacity of the human body. As the number of elderly people ...
Quality of life of women with breast cancer after radical mastectomy and its socio-demographic determinants
Volume 10, Issue №4, 2024
Background: Breast cancer is the most common malignant neoplasm among women. One of the main methods of treating breast cancer is surgery, including radical mastectomy, which, along ...
Eating disorders: neuroendocrine changes and potential treatments (review)
Volume 10, Issue №4, 2024
Background: Eating disorders (EDs) are a group of conditions with an unknown etiology, which is why a comprehensive therapy program is not yet available. The high prevalence ...
Features of the inflammatory process in patients with social isolation and age-related macular degeneration
Volume 10, Issue №4, 2024
Background: The priority problem of modern gerontology and geriatrics is currently social isolation, which represents an objective individual condition and reflects the absence of social relationships or ...
Possibilities for early diagnosis of fetal central nervous system lesions in the antenatal period (review)
Volume 10, Issue №4, 2024
Background: Fetal brain damage during pregnancy is a major cause of neonatal death and disability, as well as infantile cerebral palsy. Infants with cerebral palsy experience motor ...
Seasonal changes in students' sleep quality as predictors of «adaptation» insomnia
Volume 10, Issue №3, 2024
Background: Sleep disorders occur even at a young age and may result from environmental factors such as circannual fluctuations in hormonal background and social sleep restriction, leading ...
LHCGR gene variants are associated with ovarian response and miscarriage risk following fresh and frozen embryo transfer
Volume 10, Issue №3, 2024
Background: Currently, infertility is a widespread problem. Despite recent advances in assisted reproductive technologies, success rates still need to be improved. Understanding patients' variability and addressing it ...
Gerontological features of the effect of the new coronavirus infection on the interleukin profile, inflammation and endogenous intoxication in mature and elderly patients with coronary heart disease
Volume 10, Issue №3, 2024
Background: Coronary heart disease (CHD) is considered as an independent risk factor for COVID-19, however, the indicators of inflammation and endogenous intoxication in patients with CHD 3-4 ...
Differential expression of CYP19A1 and lncRNA-CTBP1-AS in the granulosa cells of women with polycystic ovary syndrome
Volume 10, Issue №2, 2024
Background: Hyperandrogenism is the basic indicator of polycystic ovarian syndrome (PCOS) and a key factor in its pathological processes. Patients with PCOS have higher testosterone levels along with ...
Relationship between the cognitive status of the long-living adults of the Central Federal District of the Russian Federation and socioeconomic factors: analysis of associations
Volume 10, Issue №2, 2024
Background: In recent years, an increase in the number of long-living adults has been a dominant demographic trend in Russia. This population group is highly susceptible to cognitive ...
The use of psychotropic drugs in oncological diseases (review)
Volume 10, Issue №2, 2024
Background: It is estimated that at least 25-30% of cancer patients experience mental disorders. Due to the high prevalence of these disorders among this patient population, psychotropic drugs have ...
The effect of interleukin-10 gene polymorphism in the formation of deep disorders of vaginal microbiocenosis in bacterial vaginosis
Volume 10, Issue №1, 2024
Background: Bacterial vaginosis (BV) is a common vaginal infection that causes significant gynecological and obstetric morbidity. Despite modern methods and treatment regimens, BV therapy remains a difficult ...
The molecular profile people of different ages in «normal» and with dilated cardiomyopathy
Volume 10, Issue №1, 2024
Background: Dilated cardiomyopathy (DCMP) is a cardiovascular pathology promising for consideration as a clinical model of premature aging of the body. According to the literature, sirtuins-1, 2, ...
The role of negative childhood experiences and internal stigma in the formation of motivation for the treatment of patients with mental disorders
Volume 10, Issue №1, 2024
Background: Motivation for treatment is an important component of patients' compliance to treatment of mental disorders, and its formation can be affected by different factors. The aim of ...
Features of geriatric status in patients with arterial hypertension and coronary heart disease (review)
Volume 10, Issue №1, 2024
Background: Among the geriatric syndromes associated with the pathology of the cardiovascular system, in particular arterial hypertension (AH) and coronary heart disease as one of the causes ...
Assessment of malnutrition risk in post-stroke patients: a systematic literature review
Volume 9, Issue №4, 2023
Background: Stroke is one of the main causes of death, especially when associated with malnutrition. Assessment of nutritional status in all stages of the disease is therefore mandatory ...
Features of the psychological deficit profile of elderly patients with age-associated comorbid cardiopathology
Volume 9, Issue №4, 2023
Background: With increasing age, there is an increased likelihood of cognitive impairment, anxiety-depressive syndrome among patients with comorbid arterial hypertension (AH) and coronary heart disease (CHD), which are ...
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