Genetics
Pathway directed mechanisms of anti-EGFR resistance in colorectal cancer (review)
Volume 11, Issue №1, 2025
Background: Targeting the epidermal growth factor receptor (EGFR) with cetuximab or panitumumab (anti-EGFR MAb) has been historically reserved for patients with RAS/BRAF wild-type advanced colorectal cancer (CRC). However, ...
Genetic variants of sex hormone-binding globulin and hormonal profile in patients with genital endometriosis
Volume 11, Issue №1, 2025
Background: Endometriosis is a chronic inflammatory, dyshormonal disease. Genetic factors play an important role in its development. Sex hormone imbalance is important for the occurrence, growth and ...
Relationship of transposable elements with non-coding RNAs in the development of atherosclerosis (review)
Volume 11, Issue №1, 2025
Background: Atherosclerosis is the leading cause of cardiovascular pathology in adults around the world. Association of the disease with age indicates the presence of common mechanisms for ...
Association of polymorphic locus rs4880 of superoxide dismutase 2 gene (SOD2) with Polycystic Ovary Syndrome: A meta-analysis
Volume 11, Issue №1, 2025
Background: According to WHO, approximately 8-13% of women of reproductive age suffer from polycystic ovary syndrome (PCOS), while up to 70% of women worldwide with PCOS remain ...
Characteristics of inter-locus interactions in the development of isolated and combined complications of pregnancy
Volume 10, Issue №4, 2024
Background: Pregnancy complications have a high prevalence and important medical and social implications. Genetic factors are involved in their development. The aim of the study: To study ...
Ovarian cancer: the significant of gene methylation in carcinogenesis (review)
Volume 10, Issue №4, 2024
Background: Epigenetic regulation of genes plays an important role in the development of ovarian cancer. One of these mechanisms is DNA methylation of tumor suppressor genes and ...
Impact of Aerobic Exercise on Expression of OPN and OPG Genes and Bmal1 Protein in the Bone Tissue of Diabetic Rats During Two Phases of Light and Dark Circadian Rhythm
Volume 10, Issue №4, 2024
Background: Diabetes is a major global disease with a high mortality rate.The impact of exercise on bone tissue protection in diabetic rats during circadian cycle phases is unknown. ...
Unusual chromosomal rearrangements detected by FISH in patients at high genetic risk
Volume 10, Issue №4, 2024
Background: Genetic and chromosomal causes in particular are responsible for a large percentage of pregnancy losses during the first trimester of pregnancy. Among chromosomal abnormalities, balanced or ...
Circulating platelet-derived microRNAs as potential biomarkers of STEMI in patients with hypertension
Volume 10, Issue №3, 2024
Background: Circulating extracellular platelet-derived microRNAs have been actively studied over the last decade as promising biomarkers of cardiovascular disease (CVD), since platelet activation plays a key role ...
Relationship between polymorphism rs1546155 of the GGT7 gene and the risk of ischemic stroke
Volume 10, Issue №3, 2024
Background: Since oxidative stress plays a role in the pathogenesis of ischemic stroke (IS), it is important to investigate the molecular mechanisms contributing to redox homeostasis and ...
Geno-phenotypic features of cystic fibrosis in Russian children from the Chechen and Karachay-Cherkess Republics
Volume 10, Issue №3, 2024
Background: Cystic fibrosis (CF) is an autosomal recessive disease that occurs with a frequency of 1:1,500 to 1:5,000 newborns, according to the World Health Organization. In the ...
Assessment of the relationship between marriage and migration characteristics of the population of the Belgorod region in dynamics over 130 years
Volume 10, Issue №3, 2024
Background: The importance of studying the dynamics of the population-demographic structure of the population of the south of Central Russia over several generations dictates the need to ...
Mycobacterium tuberculosis gene variants associated with drug resistance to fluoroquinolones (literature review)
Volume 10, Issue №3, 2024
Background: The spread of M. tuberculosis drug resistance to fluoroquinolones poses a threat to their long-term clinical efficacy. Understanding the mechanisms of formation of drug resistance to ...
Genetic variant rs11568818 of matrix metalloproteinase MMP7 associated with newborn weight in pregnant women with fetal growth restriction
Volume 10, Issue №2, 2024
Background: Fetal growth restriction is a common complication of pregnancy that has been associated with a variety of adverse perinatal outcomes. The condition carries significant risks of ...
Polymorphism in the matrix metallopeptidase genes is associated with coronary artery disease risk with concomitant metabolic syndrome
Volume 10, Issue №2, 2024
Background: Metabolic syndrome (MS) and its components are the reasons of the development and progression of cardiovascular diseases. Nowadays, the association between coronary artery disease and MS ...
Search for molecular markers of joint hypermobility
Volume 10, Issue №2, 2024
Background: Joint hypermobility (JH) is a condition that can be either benign or accompanied by pain and early development of osteoarthritis. For early verification of the risk of ...
HSPD1 gene polymorphism is associated with an increased risk of ischemic stroke in smokers
Volume 10, Issue №2, 2024
Background: Ischemic stroke (IS) is a leading cause of death and disability worldwide. Since the influence of vascular stressors prompts cross-reactivity with microbial and human HSPD1 (HSP60), which ...
Sex-specific features of interlocus interactions determining susceptibility to hypertension
Volume 10, Issue №1, 2024
Background: Hypertension (HT) belongs to a group of widespread diseases in both men and women, but at the same time the disease is more often registered (≈20%) in ...
Retroelements in targeted antitumor therapy (review)
Volume 10, Issue №1, 2024
Background: Pathological expression of retroelements is determined in most malignant tumors, which reflects the pathogenesis of tumors, since activated retrotransposons cause genomic instability due to a cascade of mutual ...
Mendelian randomization in eye disorders (review)
Volume 10, Issue №1, 2024
Background: Mendelian randomization (MR) is an analytic approach in genetic epidemiology which uses the results of genome-wide association studies (GWAS) to assess causal relationships between various risk ...
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