Pharmacology
Osteoprotective and regenerative effects of the plant polyphenol resveratrol in postmenopausal osteoporosis: an experimental pharmacological study
Volume 11, Issue №3, 2025
Background: Osteoporosis is one of the major metabolic, age-related skeletal diseases and a serious medical and socioeconomic problem worldwide. This is due to its steadily increasing prevalence and ...
Evaluation of the therapeutic effects of fonturacetam in the chronic unpredictable mild stress (CUMS) model in rats
Volume 11, Issue №3, 2025
Background: Chronic stress can lead to adverse consequences such as occupational burnout syndrome (OB). Considering the social significance of the disease and the lack of standard treatment, ...
Review of clinical trials of promising bispecific candidates for CAR-T cell therapy
Volume 11, Issue №3, 2025
Background: CAR-T (Chimeric Antigen Receptor T-Cell) therapy has proven to be highly effective in the treatment of oncohematological diseases. In pivotal clinical trials for CD19-positive tumors (ZUMA-1, ...
Exploring the Medicinal Potential of Jatropha gossypifolia Leaf Extract: a Comprehensive Analysis of Bioactive Compounds, Antimicrobial Activities, and Molecular Interactions in the Treatment of Atopic Dermatitis
Volume 11, Issue №3, 2025
Background: Jatropha gossypifolia, a plant traditionally recognized for its therapeutic properties, has gained scientific interest due to its potential pharmacological applications. However, comprehensive studies exploring its bioactive constituents ...
Metabolic and functional effects of complex therapy of renal and cardiovascular pathology with sodium-glucose cotransporter type 2 inhibitors in patients with diabetes mellitus and Covid-19 (review)
Volume 11, Issue №2, 2025
Background: Studying the mechanisms of development of chronic kidney pathology and concomitant disorders of the cardiovascular system in patients with type 2 diabetes mellitus (DM2) and its combination ...
Investigating Phytochemical Constituent and Anti-Anemic Properties of Polyphenol-Rich Extract from Carica papaya Leaves in a Rat Model
Volume 11, Issue №2, 2025
Background: Anemia, affecting 24.8% of the global population, is a common blood disorder caused by deficiencies in haemoglobin or red blood cells due to factors like chronic illness, ...
In-silico insights into α-Synuclein mediated pathology of Parkinson’s disease using molecular docking and molecular dynamics simulation studies
Volume 11, Issue №2, 2025
Background: The precise cause of neuronal loss in Parkinson's disease (PD) is multifactorial, involving genetic and environmental factors. Genetic mutations, affecting many proteins such as α-Synuclein, Leucine-rich repeat ...
Spectrum of anti-inflammatory, anti-infectious and anti-tumor activity of quinazoline and quinazolinone derivatives (review)
Volume 11, Issue №1, 2025
Background: A new class of medicinal compounds – derivatives of quinazoline and quinazolinone have been actively studied in recent years, on their basis drugs with polyvalent influence ...
Bioactivity of Vitamin D and Tinospora cordifolia Extract in Increasing Cathelicidin Synthesis and Regulating TNF Alpha Production in CD66a Cells
Volume 11, Issue №1, 2025
Background: Cathelicidin is an antimicrobial peptide that plays an important function in the innate immune system as the first line of defense against infections. There is still ...
Study on biological activities of herbs’ decoction combining Scutellaria barbata, Hedyotis diffusa and Ehretia asperula
Volume 10, Issue №4, 2024
Background: Cancer is a leading cause of death worldwide. Nowadays, cancer is often treated with different methods, such as surgery, radiation therapy, and chemotherapy. However, these methods ...
Effect of dalargin on the content of matrix metalloproteinases and tissue inhibitor of metalloproteinases in the colon of mice with experimental ulcerative colitis
Volume 10, Issue №4, 2024
Background: Ulcerative colitis is a chronic, multifactorial disease, the development of which is stimulated by disturbances in the microbiota of the colon, poor nutrition, an inadequate immune response ...
Effects of taftsin-pro-gly-pro peptide on heart rate variability indices in rats in different motor activities
Volume 10, Issue №3, 2024
Background: The cardiotropic effects of a synthetic peptide with the anxiolytic activity of taftsin-Pro-Gly-Pro (taftsin-PGP) under stress was investigated. Previously, the effect of this peptide on the state ...
Selection of rational tools for the analysis of polyphenols of sandy everlasting flowers and artichoke leaves in the complex of pharmacological studies
Volume 10, Issue №3, 2024
Background: Pathology of the hepatobiliary system includes a heterogeneous group of diseases of the liver and biliary system caused by viral, bacterial and parasitic infections, neoplasms, toxic chemicals, ...
Mechanisms of biological effectiveness of ionic forms of metals of variable valence in respiratory medicine
Volume 10, Issue №2, 2024
Background: The task to develop new drugs containing metals of variable valence requires systematization of our knowledge, experimental and clinical studies. The aim of the study: To investigate ...
In vitro activity of the novel antimicrobial peptide WR-286 in combination with vancomycin against methicillin-resistant
Staphylococcus aureus
Volume 10, Issue №2, 2024
Background: Multidrug resistance bacteria are a serious problem for health specialists and all the people in the world. The main reasons for this problem are the misuse ...
Potential protective effect of alpha lipoic acid against testicular oxidative stress and altered gene expression induced by gentamicin treatment
Volume 10, Issue №2, 2024
Background: Gentamicin induces testicular damage in association with oxidative stress explained by different mechanisms, including gene expression suppression of some antioxidant enzymes. The aim of the study: ...
Targeting the Bap1 protein of Vibrio cholerae for screening potent inhibitors and predicting the mutant protein stability: in silico analyses
Volume 10, Issue №1, 2024
Background: Bap1 is reported to be a major protein in Vibrio cholerae which aids in biofilm formation. Hence, inhibition of the protein molecule can no longer support the ...
Morphological changes in gum tissue during thiram intoxication followed by correction with resveratrol and sea buckthorn oil
Volume 10, Issue №1, 2024
Background: The widespread use of pesticides can lead to a violation of the ecological balance between the environment and the human body, provoking the development of oxidative ...
Curcumin Ameliorates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by Regulating Endoplasmic Reticulum Stress in The Liver
Volume 9, Issue №4, 2023
Background: Nonalcoholic fatty liver disease (NAFLD) is a chronic pathological condition of the liver due to excess triglyceride accumulation in hepatocytes. The antioxidant properties of curcumin improve lipid ...
Seasonal periodontal microcirculation by combined stress in rats corrected with complex phytoadaptogen
Volume 9, Issue №4, 2023
Background: One of the negative inducers of the internal environment is inflammation; amongst external factors the most significant is polyetiological stress. One of the promising pharmacological methods of ...
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