Pharmacology
Effects of taftsin-pro-gly-pro peptide on heart rate variability indices in rats in different motor activities
Volume 10, Issue №3, 2024
Background: The cardiotropic effects of a synthetic peptide with the anxiolytic activity of taftsin-Pro-Gly-Pro (taftsin-PGP) under stress was investigated. Previously, the effect of this peptide on the state ...
Selection of rational tools for the analysis of polyphenols of sandy everlasting flowers and artichoke leaves in the complex of pharmacological studies
Volume 10, Issue №3, 2024
Background: Pathology of the hepatobiliary system includes a heterogeneous group of diseases of the liver and biliary system caused by viral, bacterial and parasitic infections, neoplasms, toxic chemicals, ...
Mechanisms of biological effectiveness of ionic forms of metals of variable valence in respiratory medicine
Volume 10, Issue №2, 2024
Background: The task to develop new drugs containing metals of variable valence requires systematization of our knowledge, experimental and clinical studies. The aim of the study: To investigate ...
In vitro activity of the novel antimicrobial peptide WR-286 in combination with vancomycin against methicillin-resistant
Staphylococcus aureus
Volume 10, Issue №2, 2024
Background: Multidrug resistance bacteria are a serious problem for health specialists and all the people in the world. The main reasons for this problem are the misuse ...
Potential protective effect of alpha lipoic acid against testicular oxidative stress and altered gene expression induced by gentamicin treatment
Volume 10, Issue №2, 2024
Background: Gentamicin induces testicular damage in association with oxidative stress explained by different mechanisms, including gene expression suppression of some antioxidant enzymes. The aim of the study: ...
Targeting the Bap1 protein of Vibrio cholerae for screening potent inhibitors and predicting the mutant protein stability: in silico analyses
Volume 10, Issue №1, 2024
Background: Bap1 is reported to be a major protein in Vibrio cholerae which aids in biofilm formation. Hence, inhibition of the protein molecule can no longer support the ...
Morphological changes in gum tissue during thiram intoxication followed by correction with resveratrol and sea buckthorn oil
Volume 10, Issue №1, 2024
Background: The widespread use of pesticides can lead to a violation of the ecological balance between the environment and the human body, provoking the development of oxidative ...
Curcumin Ameliorates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by Regulating Endoplasmic Reticulum Stress in The Liver
Volume 9, Issue №4, 2023
Background: Nonalcoholic fatty liver disease (NAFLD) is a chronic pathological condition of the liver due to excess triglyceride accumulation in hepatocytes. The antioxidant properties of curcumin improve lipid ...
Seasonal periodontal microcirculation by combined stress in rats corrected with complex phytoadaptogen
Volume 9, Issue №4, 2023
Background: One of the negative inducers of the internal environment is inflammation; amongst external factors the most significant is polyetiological stress. One of the promising pharmacological methods of ...
Stress-protective activity of Astragalus physodes extract on the model of «social» stress
Volume 9, Issue №3, 2023
Background: In recent decades, in the conditions of human existence, special attention has been paid to the problem of stress and the body's response to the impact of stress ...
Effect of pyrimidine derivative on cytokine levels in experimental generalized staphylococcal infection
Volume 9, Issue №3, 2023
Background: To date, bacterial infections caused by microorganisms characterized by antibiotic resistance are one of the leading causes of the protracted course of infectious and inflammatory diseases that occur with ...
Pharmacological potential of ar-turmerone and study of the extractive potential of fluorinated alkane derivatives for its isolation from the rhizomes of Curcuma longa L.
Volume 9, Issue №2, 2023
Background: Ar-turmerone is one of the main components of the essential oil of the rhizomes of Curcuma longa L. It determines the specificity of the composition of the essential ...
Effects of complex phytoadaptogens in matobolic syndrome
Volume 9, Issue №2, 2023
Background: The widespread prevalence of metabolic syndrome (MS) is becoming a serious problem for the population around the world, increasing the risk of developing type 2 diabetes and complications ...
State of colon parietal microbiota and antioxidant properties of colonocytes in rats with ecological dysbiosis treated with sea vitamin E and buckthorn oil
Volume 9, Issue №1, 2023
Background: When the macroorganism is exposed to pesticides, qualitative and/or quantitative changes in the microbiocenosis composition occur – dysbiosis. As a result of this action, lipid peroxidation is enhanced ...
Pathological conditions associated with tau protein: mechanisms of development and possible biological targets for pharmacological correction of tau proteinopathy (review)
Volume 8, Issue №4, 2022
Background: The pathological process associated with the pathogenic aggregation of tau is called taupathy. The same term is often used to refer to a group of neurodegenerative diseases, an ...
The role of cortisol metabolism in the realization of pathogenetic links in the development of osteoporosis – the rationale for the search for new pharmacotherapeutic targets (review)
Volume 8, Issue №4, 2022
Background: Osteoporosis is an important medical and social public health problem in an aging or elderly society. Osteoporosis is caused by an imbalance in bone remodeling, which is a ...
Correction of mitochondrial dysfunction with cinnamic acids in experimental hypercytokinemia
Volume 8, Issue №3, 2022
Background: Mitochondrial dysfunction is an essential component of the hypercytokine neurotoxicity pathogenesis and is a promising pharmacotherapeutic target. The aim of the study: To evaluate the effect of cinnamic acids ...
Studies to elucidate the effect and antiapoptotic mechanism of 2-ethyl-3-hydroxy-6-methylpyridine-n-acetyltaurinate in a rat model of retinal ischemia–reperfusion
Volume 8, Issue №3, 2022
Background: The study of possible ways of effective correction of retinal ischemia-reperfusion injury, which accompanies a number of eye diseases, is relevant today. The aim of the study: To study ...
In silico identification of the potential natural inhibitors of SARS-CoV-2 Guanine-N7 methyltransferase
Volume 8, Issue №3, 2022
Background: The outbreak of the COVID-19 pandemic caused by the SARS-CoV-2 has triggered intense scientific research into the possible therapeutic strategies that can combat the ravaging disease. One of ...
Pharmacological characteristics of intranasal dosage forms containing Ginkgo biloba extracts
Volume 8, Issue №2, 2022
Background: This article reviews the pharmacological characteristics of developed dosage forms for intranasal administration. The influence of the type of dosage form on the efficacy of the drug ...
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